Authorities in northern Greece say they are helping dozens of passengers injured in train collision and fiery derailment early Wednesday.

The collision between a freight train and and oncoming passenger train occurred near Tempe, some 380km north of Athens, and resulted in the derailment of several train cars, police said.

At least three of the derailed cars caught fire.

READ MORE: Dozens of cough medicines recalled over potentially deadly ingredient

Smoke rises from trains as firefighters and rescuers operate after a collision near Larissa city, Greece.

Vehicles from the fire and ambulance services were sent to the scene from several nearby towns to help transport injured passengers and free others trapped in the wreckage.

Government officials said the army had been contacted to assist in the rescue and that two additional hospitals in the nearby city of Larissa had been placed in emergency duty.

Local media has reported at least six people are feared dead so far.

More to come.

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