A recent study reveals that individuals using weight loss medications typically experience a rebound in weight and a return of adverse health indicators within two years.

Published in the British Medical Journal (BMJ), the research indicates that not only does the weight return, but elevated cholesterol and high blood pressure also reappear.

According to the findings, the average weight regain rate is about 0.4 kilograms per month after discontinuing the medication. Consequently, weight and risk factors for conditions like diabetes and heart disease are likely to revert to pre-treatment levels in under two years.

The study also highlights that the pace of weight regain post-medication cessation is nearly four times quicker than that following lifestyle changes involving diet and exercise, regardless of the initial weight loss amount.

“The evidence points to the fact that, while these medications are effective for initial weight reduction, they may not suffice for sustainable long-term weight management,” the researchers commented.

While the drugs are wildly popular and have transformed the treatment of obesity, it’s estimated that around half of people with obesity discontinue GLP-1 drugs within 12 months.

“The study findings cast doubt on the notion that GLP-1 receptor agonists are a perfect cure for obesity,” a US researcher said in a linked editorial.

“People taking GLP-1 receptor agonists should be aware of the high discontinuation rate and the consequences of cessation of medications.”

He said “healthy dietary and lifestyle practises” should remain the foundation of weight loss treatment and management, with the GLP-1 medications used as an aide.

“Such practises not only help prevent excess weight gain but can also lead to numerous health benefits that go beyond weight control,” he said.