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In the late ’90s, when “ER” was a ratings phenomenon for NBC (via The Los Angeles Times), George Clooney was also winning roles in several major Hollywood movies while maintaining his part in the hit series. This was one of the real reasons Clooney left the show, despite its success with the American TV viewing public. Movies and television were seen as two entirely different mediums in that era, with the small screen never quite reaching the stature and prestige it holds today. But his leaving the show did not affect the relationships with his co-actors, as he revealed in an interview on “The Drew Barrymore Show” (per ET Canada).
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After Barrymore mentioned the show and his former colleagues, Clooney commented, “I guess it was the friendship I have with all of them and that I continue to have.” He then spoke about individual co-stars and continued, “I had [Anthony] Tony Edwards at the house in Italy three weeks ago — he and Mare [Winningham, his wife] came.” He added that he is also still “really close” with co-stars Julianna Margulies and Noah Wyle. He concluded with, “They’re really good friends [Margulies and Wyle],” Clooney tells Barrymore in the clip. “And so, I feel that [show] was a job of a lifetime. And it changed my career.”