A man has been arrested following an hours-long standoff in Brisbane that led to an exclusion zone being set up.

Queensland Police started chasing the blue Volkswagen Amarok Polar in the early hours of this morning.

The chase continued before tyre spikes were deployed on Old Cleveland Road, finally dragging the car to slow a halt.

Police say two people inside the car then fled on foot in opposite directions.

One was quickly arrested while the other evaded police for hours, sparking a major operation to bring him into custody.

An exclusion zone was set up between Daveson Road, Old Cleveland Road, north to the parallel of Fleet street and to Abelia Street.

Hundreds of residents wee urged to stay inside their homes for their own safety.

Dozens of police rushed to the scene and tracked down the man, who was arrested at 5am Queensland time.

The exclusion zone has been lifted and the street has been reopened.