DUBAI, United Arab Emirates — Israel appeared to be expanding its air campaign on Tehran five days after its surprise attack on Iran’s military and nuclear program, as U.S. President Donald Trump posted an ominous message warning residents of the capital to evacuate.

“IRAN CAN NOT HAVE A NUCLEAR WEAPON,” Trump wrote Monday night before returning to Washington early from a Group of Seven summit in Canada. “Everyone should immediately evacuate Tehran!” he added.

Trump later denied he had rushed back to work on a ceasefire, telling reporters on Air Force One during the flight back to Washington: “I’m not looking at a ceasefire. We’re looking at better than a ceasefire.”

Asked why he had urged for the evacuation of Tehran, he said: “I just want people to be safe.”

Earlier, the Israeli military had called for some 330,000 residents of a neighborhood in downtown Tehran to evacuate. Tehran is one of the largest cities in the Middle East, with around 10 million people, roughly equivalent to the entire population of Israel. People have been fleeing since the hostilities began.

Israel says its sweeping assault on Iran’s top military leaders, nuclear scientists, uranium enrichment sites and ballistic missile program is necessary to prevent its longtime adversary from getting any closer to building an atomic weapon. The strikes have killed at least 224 people in Iran and wounded 1,277 since Friday.

Iran has retaliated by launching more than 370 missiles and hundreds of drones at Israel. So far, 24 people have been killed in Israel and more than 500 wounded. The Israeli military said a new barrage of missiles was launched on Tuesday, and explosions could be heard in northern Israel.

Downtown Tehran appeared to be emptying out early Tuesday, with many shops closed. The ancient Grand Bazaar was also closed, something that only happened in the past during anti-government demonstrations or at the height of the coronavirus pandemic.

On the roads out of Tehran to the west, traffic stood bumper to bumper. Many appeared to be heading to the Caspian Sea area. Long lines also could be seen at gas stations in Tehran, with printed placards and boards calling for a “severe” response to Israel visible across the city.

Authorities cancelled leave for doctors and nurses as the attacks continue, but insisted everything was under control and did not offer any guidance for the public on what to do.

The Israeli military meanwhile claimed to have killed someone it described as Iran’s top general in a strike on Tehran. Iran did not immediately comment on the reported killing of Gen. Ali Shadmani, who had just been named as the head of the Khatam al-Anbiya Central Headquarters, part of the paramilitary Revolutionary Guard.

Iran has named other generals to replace the top leaders of the Guard and the regular armed forces after they were killed in earlier strikes.

Before leaving the summit in Canada, Trump joined the other leaders in a joint statement saying Iran “can never have a nuclear weapon” and calling for a “de-escalation of hostilities in the Middle East, including a ceasefire in Gaza.”

French President Emmanuel Macron told reporters that discussions were underway on a ceasefire between Israel and Iran, but Trump appeared to shoot that down in his comments on social media.

Macron “mistakenly said that I left the G7 Summit, in Canada, to go back to D.C. to work on a ‘cease fire’ between Israel and Iran,” Trump wrote. “Wrong! He has no idea why I am now on my way to Washington, but it certainly has nothing to do with a Cease Fire. Much bigger than that.”

Meanwhile, U.S. Defense Secretary Pete Hegseth headed to the White House Situation Room to meet with the president and his national security team.

Hegseth didn’t provide details on what prompted the meeting but said on Fox News late Monday that the movements were to “ensure that our people are safe.”

Trump said he wasn’t ready to give up on diplomatic talks, and could send Vice President JD Vance and special envoy Steve Witkoff to meet with the Iranians.

“I may,” he said. “It depends on what happens when I get back.”

Israeli military spokesperson Brig. Gen. Effie Defrin said Monday his country’s forces had “achieved full aerial superiority over Tehran’s skies.”

The military said it destroyed more than 120 surface-to-surface missile launchers in central Iran, a third of Iran’s total, including multiple launchers just before they launched ballistic missiles towards Israel. It also destroyed two F-14 fighter planes that Iran used to target Israeli aircraft, the military said.

Israeli military officials also said fighter jets had struck 10 command centers in Tehran belonging to Iran’s Quds Force, an elite arm of its paramilitary Revolutionary Guard that conducts military and intelligence operations outside Iran.

Israel’s military issued an evacuation warning for a part of central Tehran that houses state TV and police headquarters, as well as three large hospitals, including one owned by the Guard. It has issued similar evacuation warnings for parts of the Gaza Strip and Lebanon ahead of strikes.

On Monday, an Israeli strike hit the headquarters of Iran’s state-run TV station, sending a television anchor fleeing her studio during a live broadcast. The Israeli military said Tuesday it had hit the station because “the broadcast channel was used to spread anti-Israel propaganda.”

Prime Minister Benjamin Netanyahu said the Israeli strikes have set Iran’s nuclear program back a “very, very long time,” and told reporters he is in daily touch with Trump.

Iran maintains its nuclear program is peaceful, and the U.S. and others have assessed Tehran has not had an organized effort to pursue a nuclear weapon since 2003. The head of the International Atomic Energy Agency has repeatedly warned that the country has enough enriched uranium to make several nuclear bombs should it choose to do so.

So far, Israel has targeted multiple Iranian nuclear program sites but has not been able to destroy Iran’s Fordo uranium enrichment facility.

The site is buried deep underground — and to eliminate it, Israel may need the 30,000-pound (14,000-kilogram) GBU-57 Massive Ordnance Penetrator, a U.S. bunker-busting bomb that uses its weight and sheer kinetic force to reach deeply buried targets. Israel does not have the munition or the bomber needed to deliver it. The penetrator is currently delivered by the B-2 stealth bomber.

Iran’s foreign minister, Abbas Araghchi, appeared to make a veiled plea Monday for the U.S. to step in and negotiate an end to hostilities.

In a post on X, Araghchi wrote that if Trump is “genuine about diplomacy and interested in stopping this war, next steps are consequential.”

“It takes one phone call from Washington to muzzle someone like Netanyahu,” Iran’s top diplomat wrote. “That may pave the way for a return to diplomacy.”

The message to Washington was sent as the latest talks between the U.S. and Iran were canceled over the weekend after Israel’s surprise bombardment.

On Sunday, Araghchi said Iran will stop its strikes if Israel does the same.

Melzer reported from Nahariya, Israel. Associated Press writers Nasser Karimi and Amir Vahdat in Tehran, Iran, Melanie Lidman in Tel Aviv, Israel, and Tara Copp in Washington contributed to this report.

Copyright 2025 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.