Angela Craig’s lifelong best friend took the stand Monday as the Colorado murder trial of dentist James Craig entered its second week, telling jurors that the mother of six was never the kind of woman who gave up easily.

“She wasn’t a risk-taker. She wasn’t manipulative,” Nicole Harmon told the court. “And she never said anything — ever — about wanting to die.”

Dr. James Toliver Craig, 47, is charged with first-degree murder in the March 2023 death of his wife, 43-year-old Angela Craig. Her cause of death was determined to be lethal doses of cyanide and tetrahydrozoline.

Investigators alleged in court documents obtained by Fox News Digital that, in the weeks before his wife’s hospitalization and death, James used a dental office computer to search for “undetectable poisons” and how to obtain them (later purchasing arsenic and cyanide by mail), “how many grams of pure arsenic will kill a human” and “is arsenic detectable in an autopsy?”

Alongside these online searches, investigators alleged he made YouTube queries such as “how to make poison” and “Top 5 Undetectable Poisons That Show No Signs of Foul Play.”

Fox News Digital has reached out to James Craig’s lead attorney, Lisa Fine Moses, for comment.