MEXICO CITY – A day after President Donald Trump dramatically stepped up his administration’s military role in the Caribbean with what he called a deadly strike on a Venezuelan drug cartel, Secretary of State Marco Rubio is meeting the president of Mexico, who has voiced fears of the U.S. encroaching on Mexican sovereignty.

Rubio will sit down with Mexican President Claudia Sheinbaum on Wednesday to stress the importance the U.S. places on cooperating with Washington on Western Hemisphere security, trade and migration. Rubio will visit Ecuador on Thursday on his third trip to Latin America since taking office.

Trump has alienated many in the region with persistent demands and threats of sweeping tariffs and massive sanctions for refusing to follow his lead, particularly on migration and the fight against drug cartels. Likely to heighten their concerns is the expanded military footprint. The U.S. has deployed warships to the Caribbean and elsewhere off Latin America, culminating in what the administration said Tuesday was a lethal strike on an alleged Tren de Aragua gang vessel that U.S. officials say was carrying narcotics.

“Please let this serve as notice to anybody even thinking about bringing drugs into the United States of America. BEWARE!” Trump said of the strike, which he said had killed 11 gang members.

Rubio, defending the strike, made clear that such operations would continue if needed. Though it was a military strike, America’s top diplomat tweeted about it around when Trump announced it in the White House and then spoke to reporters about the operation.

“The president has been very clear that he’s going to use the full power of America and the full might of the United States to take on and eradicate these drug cartels, no matter where they’re operating from and no matter how long they’ve been able to act with impunity,” Rubio said Tuesday. “Those days are over.”

Rubio, a son of Cuban immigrants, has spoken out against Venezuelan leader Nicolas Maduro and other Latin American leftist governments, notably in Cuba and Nicaragua, for years and supported opposition leaders and movements there. Just before leaving for Mexico, he attended an award ceremony in Florida for a Cuban dissident who he said was an inspiration for freedom-loving people everywhere.

In Mexico, Trump has demanded, and so far won, some concessions from Sheinbaum’s government, which is eager to defuse his tariff threats, although she has fiercely defended Mexico’s sovereignty.

“There will be moments of greater tension, of less tension, of issues that we do not agree on, but we have to try to have a good relationship,” she said shortly before Rubio arrived in Mexico City on Tuesday.

Earlier this week, in a State of the Nation address marking her first year in office, she said: “Under no circumstance will we accept interventions, interference or any other act from abroad that is detrimental to the integrity, independence and sovereignty of the country.”

Sheinbaum has gone after Mexican drug cartels and their fentanyl production more aggressively than her predecessor. The government has sent the National Guard to the northern border and delivered 55 cartel figures long wanted by U.S. authorities to the Trump administration.

Sheinbaum had spoken for some time about how Mexico was finalizing a comprehensive security agreement with the State Department that, among other things, was supposed to include plans for a “joint investigation group” to combat the flow of fentanyl and the drug’s precursors into the U.S. and weapons from north to south.

Last week, however, a senior State Department official downplayed suggestions that a formal agreement — at least one that includes protections for Mexican sovereignty — was in the works.

Sheinbaum lowered her expectations Tuesday, saying it would not be a formal agreement but rather a kind of memorandum of understanding to share information and intelligence on drug trafficking or money laundering obtained “by them in their territory, by us in our territory unless commonly agreed upon.”

On the trip, Rubio would focus on stemming illegal migration, combating organized crime and drug cartels, and countering what the U.S. believes is malign Chinese behavior in its backyard, the State Department said.