Amy Schumer enjoyed the ‘night of a lifetime’ with two gal pals in Las Vegas, NV on Saturday.

The 44-year-old comedian flaunted her significant weight loss, achieved through Mounjaro, by wearing a stylish, black Miu Miu mini-dress complemented with cha-cha heels.

It’s the slimmest Amy has appeared since starting the popular GLP-1 agonist medication earlier this year, and she received congratulatory comments from Chelsea Handler, Amy Sedaris, Isla Fisher, and Lee Daniels.

Schumer was in Sin City to attend Sir Paul McCartney’s concert at Allegiant Stadium.

The Emmy-winning producer, who has 16.6M followers on social media, shared an Instagram slideshow filled with memories from the show, including the prized set list.

Amy was joined in the VIP section by her ‘lovies’ Jillian Bell and Alex Saks.

Amy Schumer (M) enjoyed the ‘night of a lifetime’ with two gal pals in Las Vegas, NV on Saturday

2025 vs. 2024: The 44-year-old comedian showcased her substantial weight loss – courtesy of Mounjaro – by donning a leggy, black Miu Miu mini-dress with cha-cha heels

Alex produced Tyler Spindel’s dismally-reviewed rom-com Kinda Pregnant, which dropped February 5 on Netflix – starring Amy as lying Lainy and Jillian as her friend Kate.

The trio of ladies were thrilled when they were captured by the cameraman, who projected their image on the large screen behind the 83-year-old Beatle.

Amy also showcased her shrinking 5ft7in frame in a b&w sleeveless mini-dress while attending the Eagles concert at the Sphere on Friday night.

Schumer is still recovering from a laminectomy she underwent in August to fix her ‘L5’ following an old surfing injury.

On April 9, the native New Yorker gushed: ‘I’m loving being on Mounjaro and I haven’t found that it’s affected anything.’

It was a few weeks after Amy updated her fans: ‘Mounjaro’s been great. Look, it’s not covered by insurance unless you have diabetes or severe obesity, which most of the internet thinks I have, but I’m having a really good experience with it and I wanted to keep it real with you about that.’

Schumer previously had a ‘horrible experience’ taking Ozempic in 2022 – the same year she underwent liposuction – because she was bedridden due to nausea.

‘I was like, vomiting — and then you have no energy. But other people take it, and they’re all good. So, God bless them,’ the Love Island US guest star recalled on The Howard Stern Show January 29.

‘I was vomiting and I’m in bed and my [six-year-old son Gene] was like, “Can you like play tag?” And I’m like, “I can’t.” I was, like, shriveling. I lost 30lbs so quick. I looked great and I couldn’t lift my head off the pillow, so what’s the point?!’

It’s the skinniest Amy has looked since going on the trendy GLP-1 agonist drug earlier this year, and she received congratulatory comments from Chelsea Handler, Amy Sedaris, Isla Fisher, and Lee Daniels

Schumer was in Sin City to attend Sir Paul McCartney’s concert at Allegiant Stadium

The Emmy-winning producer – who boasts 16.6M social media followers – shared an Instagram slideshow full of memories of the show including the coveted set list

Amy was joined in the VIP section by her ‘lovies’ Jillian Bell (L) and Alex Saks (M)

Alex produced Tyler Spindel’s dismally-reviewed rom-com Kinda Pregnant, which dropped February 5 on Netflix – starring Amy as lying Lainy and Jillian as her friend Kate

The trio of ladies were thrilled when they were captured by the cameraman, who projected their image on the large screen behind the 83-year-old Beatle

Amy also showcased her shrinking 5ft7in frame in a b&w sleeveless mini-dress while attending the Eagles concert at the Sphere on Friday night

Schumer is still recovering from a laminectomy she underwent in August to fix her ‘L5’ following an old surfing injury (pictured July 10) 

On April 9, the native New Yorker gushed: ‘I’m loving being on Mounjaro and I haven’t found that it’s affected anything’

It was a few weeks after Amy updated her fans: ‘Mounjaro’s been great. Look, it’s not covered by insurance unless you have diabetes or severe obesity, which most of the internet thinks I have, but I’m having a really good experience with it and I wanted to keep it real with you about that’

Schumer previously told The Howard Stern Show January 29 that she had a ‘horrible experience’ taking Ozempic in 2022 – the same year she underwent liposuction – because she was bedridden due to nausea (pictured January 29) 

The Love Island US guest star recalled: ‘I was vomiting and I’m in bed and my [six-year-old son Gene] was like, “Can you like play tag?” And I’m like, “I can’t.” I was, like, shriveling. I lost 30lbs so quick. I looked great and I couldn’t lift my head off the pillow, so what’s the point?!’ (pictured May 25)

Amy and her husband of seven years, Chris Fischer (R, pictured February 3), enlist a nanny called Jane and they have three frozen embryos to eventually provide a sibling, via surrogate, for their child

The 45-year-old chef – who has Asperger’s Syndrome – inspired the Midi Health investor to executive produce Alexander Hammer’s autism documentary Room to Move, which screens this Friday at the Film Festival at Hollywood Park in LA

The FDA has only approved three GLP-1 drugs specifically for weight loss – the semaglutide Wegovy, the liraglutide Saxenda, and the tirzepatide Zepbound – and the rest are specifically for patients suffering from type 2 diabetes.

Celebrities who’ve admitted to taking the diabetic injectables include Oprah Winfrey, Kathy Bates, Kelly Clarkson, Whoopi Goldberg, Serena Williams, Meghan Trainor, Elon Musk, Rebel Wilson, Chelsea Handler, Amy Schumer, Sharon Osbourne, and Tori Spelling.

But for every celebrity who admits to hopping aboard the Ozempic train, there are many more who’ve remained suspiciously silent while slimming including Selena Gomez, Mindy Kaling, Melissa McCarthy, Khloé Kardashian, Demi Lovato, Lana Del Rey, Christina Aguilera, and Ricki Lake.

Amy and her husband of seven years, Chris Fischer, enlist a nanny called Jane and they have three frozen embryos to eventually provide a sibling, via surrogate, for their child.

Schumer met the 45-year-old chef – who has Asperger’s Syndrome – through her personal assistant (his sister) just five months before tying the knot.

Chris inspired the Midi Health investor to executive produce Alexander Hammer’s autism documentary Room to Move, which screens this Friday at the Film Festival at Hollywood Park in LA.

Amy will also serve producing and script editing duties on Yadin Gellman’s rom-com Now More Than Ever about an Israeli wounded soldier who become a national ‘poster boy’ following the October 7, 2024 Hamas attack and goes on a hasbara journey to New York.