Bills vs. Jaguars, Eagles vs. 49ers predictions: NFL Wild Card weekend picks, odds
Share and Follow

Dylan Svoboda, a seasoned sports betting analyst, returns to The Post’s Bettor’s Guide for his sophomore season.

Buffalo Bills (+0.5) over JACKSONVILLE JAGUARS

As the Buffalo Bills, led by Josh Allen, prepare to challenge the surging Jaguars on their turf, we’re looking at the weekend’s closest betting line.

In this matchup, I’m putting my faith in experience.

Although the Jaguars have become a popular dark horse in the AFC, I remain cautious about banking on Trevor Lawrence, who boasts only a single playoff victory, and their new head coach, Liam Coen.

Despite an unremarkable regular season, the Bills capped the year with significant away victories in Pittsburgh, New England, and the notoriously challenging Cleveland.

Allen, who has been visibly banged up for weeks, got some much-needed rest last week, playing just one snap in Week 18 against the Jets. 

Look for their superstar quarterback to play Superman with some fresh legs.


Two Eagles players, one wearing number 20 and the other number 1, in green uniforms, during a handoff.
Philadelphia Eagles quarterback Jalen Hurts (1) hands off the ball to Philadelphia Eagles running back Saquon Barkley, left, during the first half of an NFL football game against the Las Vegas Raiders on Sunday, Dec. 14, 2025, in Philadelphia. AP

PHILADELPHIA EAGLES (-4) over San Francisco 49ers

A week ago, the 49ers had a shot at a first-round bye with the potential to never leave the Bay Area through the Super Bowl.  

It’s all gone wrong for them since then. They lost to the Seahawks, missed the NFC’s No. 1 seed, and suffered even more injuries to their already depleted roster.

Linebacker Tatum Bethune went down with a groin injury, and it appears dicey at best that the team will get star left tackle Trent Williams and wide receiver Ricky Pearsall, who both didn’t practice on Wednesday, back on Sunday. 


Betting on the NFL?


It’s amazing this team has even gotten this far.

Traveling across the country isn’t going to help, and it will be tough to turn this game into a shootout against the Eagles’ defense. 

San Francisco’s luck might run out on Sunday.

LAST WEEK: 1-1.

2025 SEASON: 15-21.


Why Trust New York Post Betting

Dylan Svoboda is a versatile writer and analyst across many sports. He’s particularly knowledgeable about the big three — MLB, the NFL and the NBA.

Share and Follow
You May Also Like
Huge $25MILLION reward offered for capture of Maduro's right-hand man

$25 Million Bounty Announced for the Arrest of Key Maduro Associate

The Trump administration has announced a $25 million bounty for information that…
Bob Weir dead at 78: Grateful Dead guitarist passes after cancer fight

Grateful Dead Guitarist Bob Weir Passes Away at 78 After Battle with Cancer

Bob Weir, the legendary guitarist and one of the founding members of…
JSO: College Park shooting stems from argument during video games

Jacksonville Police Seek Suspect in Doorstep Shooting Incident

A man is on the mend after being shot by an unidentified…
Anti-ICE protests explode across the country after Renee Good's death

Nationwide Protests Erupt Following the Death of Renee Good, Sparking Anti-ICE Sentiment

Anger over the tragic shooting of a Minnesota activist by a federal…
Exclusive | Slow release of security video in Christmas Day slay of Long Island CVS worker prompts proposed law

Exclusive: New Legislation Proposed After Delayed Release of Security Footage in Long Island CVS Christmas Day Tragedy

Police on Long Island have expressed frustration over CVS’s delayed release of…
Nicola Peltz removes Beckham family from social media

Nicola Peltz’s Surprising Social Media Move: Why She Unfollowed the Beckhams

Nicola Peltz has wiped her social media clean of any mention of…
Nobel Institute clarifies Peace Prize rules as Machado offers award to Trump

The Nobel Institute Sets Record Straight on Peace Prize Protocol Amidst Machado’s Proposal for Trump

Venezuelan opposition leader María Corina Machado recently expressed her desire to share…
College Football Playoff final: Indiana University, University of Miami to face off in title matchup that once seemed impossible

Indiana and Miami Set for Unlikely Showdown in College Football Playoff Final

Just two months ago, such a scenario seemed unlikely. Turn the clock…