An investigation is under way into a suspicious fire that engulfed a medical clinic in Melbourne's north overnight. 

Emergency services were called to a home used as a medical clinic near the corner of Gaffney and Derby streets in Pascoe Vale about 9.30pm yesterday.

They arrived to find the building entirely consumed by flames.

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No one was inside at the time, but the fire threatened nearby properties whose residents were evacuated as a precaution.

A warning over smoke in the area was issued while firefighters worked to contain the blaze to the medical clinic, which suffered a structural roof collapse.

The fire was brought under control about 50 minutes later. 

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No injuries were reported.

Fire Rescue Victoria and Victoria Police have deemed the fire suspicious, and a crime scene has been declared at the home.

An arsonist chemist will assess the scene today.

Police urge anyone with information or footage to contact Crime Stoppers.

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