Standup comic and first-time Golden Globes host Nikki Glaser opened the show with pointed jokes but not the barbed roasts she’s known for.

“Welcome to the 82nd Golden Globes, Ozempic’s biggest night,” Glaser opened with.

“If you’re watching on Paramount+, you have six days left to cancel your free trial.”

Award-winning movie Wicked and star Timothee Chalamet, and his moustache, were early targets.

“I loved ‘Wicked,’ my boyfriend loved ‘Wicked,’ my boyfriend’s boyfriend REALLY loved ‘Wicked,” she said.

To a mustachioed Chalamet Glaser added: “You have such beautiful eyelashes on your upper lip.”

Glaser said she said she doesn’t plan to roast the room because the people in it are powerful and can do anything “except tell people who to vote for”, referencing the celebrity endorsements of Kamala Harris in last year’s US Election.

While addressing Zendaya, Glaser brought up Sean “Diddy” Combs’ recent indictments.

Diddy has pleaded not guilty to charges that he coerced and abused women for years with the aid of a network of associates and employees while silencing victims through blackmail and violence, including kidnapping, arson and physical beatings. He has denied the allegations.

“‘Challengers,’ girl, oh my god, it was so good. I mean, that movie was more sexually charged than Diddy’s credit card,” Glaser joked.

“I mean, seriously? Oh, no, no, I know, I’m sorry. I’m upset too. The afterparty is not going to be as good this year, but we have to move on. I know ‘Stanley Tucci Freak Off’ just doesn’t have the same ring to it.”

She was not nearly as ruthless or as dirty as she was in May at the Netflix “Roast of Tom Brady” in a show-stealing appearance that helped her get the Globes gig.

– With Associated Press