Amy Schumer revealed she’s on a new weight loss medication after her last attempt on the drugs left her so nauseous she couldn’t lift her head off the pillow.

“Mounjaro’s been great,” the comedian said in an Instagram video Friday, noting that the medicine isn’t covered by insurance unless a patient has diabetes or severe obesity.

“Which most of the internet thinks I have,” she joked. “But I’m having a really good experience with it and I wanted to keep it real with you about that.”

Earlier in the video, Schumer, 43, detailed trying Wegovy three years earlier saying she couldn’t stop puking.

“I couldn’t handle it. I don’t know if they’ve changed the formula, whatever,” the “Kinda Pregnant” actress said.

While both drugs are used to help with weight loss, Mounjaro has been FDA-approved to treat Type II Diabetes, while Wegovy has not, according to Healthline.

In the video, during which she was promoting Midi Health — a telehealth company that specializes in health for women above 35 — Schumer announced she was in perimenopause, the period between a woman’s reproductive years and menopause.

“They put me on estrogen and progesterone … and my symptoms from being perimenopause have disappeared,” Schumer, an investor in Midi Health, said. “My hair is fuller, my skin is better, I have more energy, I want to get down more, if you know what I mean. I’m talking about sex.”

In January, Schumer revealed she dropped 30 pounds when she was taking the weight loss drugs, though at the time she said she used Ozempic.

“I was like, vomiting — and then you have no energy. But other people take it and they’re all good. God bless them,” she told Howard Stern on his SiriusXM talk show, calling it a “horrible experience.”

Schumer said even though she “looked great,” she couldn’t “lift my head off the pillow” from how nauseous she was on the drug.

The “Trainwreck” star — who shares one son with husband Chris Fischer — first addressed using weight loss drugs in June 2023 when she called out other celebrities for lying about it.

“You are on Ozempic or one of those things or you got work done. Just stop,” Schumer told “everyone” hiding their use of the Type II diabetes drug.

“Be real with the people,” she added. “When I got lipo, I said I got lipo.”