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Friends of Christina Applegate are expressing deep concern for the “Married… With Children” actress following her recent hospitalization, as troubling new details emerge regarding her ongoing battle with multiple sclerosis.
In an interview with the Daily Mail, a source shared on Friday, “Each setback brings the harsh reality to the forefront—that time with her might be limited.”
While describing Christina’s resilience, the source noted, “Her struggle with MS has been daunting. She experiences a mix of better and worse days, but never truly great ones. There’s always something she’s contending with, which is incredibly tough.”
The insider also highlighted, “Despite the challenges, finding positivity helps Christina in the moment. She is surrounded by friends who offer their unwavering support, whether it’s listening, sharing tears, or just being present.”
This latest update follows news of Applegate, now 54, being admitted to a Los Angeles hospital last month.
It remains unclear if the reason behind her extended hospital visit has to do with her autoimmune disease at this time.
When reached for comment, a rep for the actress told Page Six: “I have no comment on whether she is in the hospital or what her medical treatments are. She’s had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.”
Applegate — who revealed her MS diagnosis in August 2021 — has been open about her health journey, giving updates via various interviews and her “MesSy” podcast, which she co-hosts with Jamie-Lynn Sigler.
Most recently, she admitted in February that she’s been confined to her bed due to ongoing pain. She made the confession while telling People that she still tries to take her daughter, Sadie — who she shares with her husband Martyn LeNoble — to school in the mornings.
“I want to take her; it’s my favorite thing to do. It’s the only time we have together by ourselves,” she told the outlet.
“I tell myself, ‘Just get her there safely and get home so you can get back into bed.’ And that’s what I do.”
Applegate last revealed she was hospitalized on an August 2025 episode of her podcast, sharing that she was “screaming” from being in “so much pain.”
On the episode, she recalled feeling like “my appendix is bursting” after she felt an excruciating pain on her side.
At the time, doctors informed her that she had a kidney infection that has since spread to her other kidney.