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By now, you’ve likely come across the term “Ozempic face,” which describes the hollow and sunken appearance some individuals develop after rapid weight loss attributed to certain medications. Many celebrities exhibit this look, with Melissa McCarthy showing subtle signs, while others, like Ryan Seacrest, may have experienced more drastic changes. Interestingly, there’s also a phenomenon known as “Ozempic neck,” and Oprah Winfrey exemplifies this condition.
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A comparison of her photos from 2014 to 2024 highlights signs commonly linked to GLP-1 usage, such as sagging and wrinkled neck skin. The most noticeable feature of her “Ozempic neck” is the presence of multiple vertical bands and the hollow areas between them. While her case might not be the most pronounced example of “Ozempic face,” it is certainly evident in her neck.
Oprah Winfrey’s appearance suggests she may have hastened her use of the weight-loss drug. Fortunately, there are several procedures available to address these side effects, ranging from radio-frequency microneedling to minor surgical options like a facelift.
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Comparing her photos from 2014 to 2024, it’s clear that Winfrey exhibits signs commonly associated with GLP-1 use, including sagging and wrinkled skin on her neck. Perhaps the most noticeable aspect of her Ozempic neck, though, are the multiple vertical bands along her neck and the hollow spaces between them. Granted, hers is hardly the most striking case of Ozempic face, but it absolutely shows in her neck.
Oprah Winfrey has no regrets about her weight loss
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Based on her Ozempic neck, it appears that Oprah Winfrey may have rushed her use of the weight-loss drug. The good news is that there are multiple procedures available to treat this unwelcome side effect, from radio-frequency microneedling to minor surgery such as a facelift.
Prevention is always better than a cure, though, so doctors strongly recommend that people take things slow if they do use these drugs. “While taking GLP-1 medications, your healthcare provider will monitor the rate at which you’re losing weight to prevent rapid weight loss that can increase the chance of the loose skin that some see as ‘Ozempic neck,’” physician Raoul Manalac, M.D., told Good Housekeeping. It’s also important to pair it with hydration, quality sleep, exercise, and diet, which are all essential for skin regeneration.
Winfrey knows that using GLP-1 drugs isn’t a miracle solution; it also requires hard work and patience — a lot of it. “You need to start slow and gradual,” she told People in 2025. “If you start by taking too much at one time, you have more of a chance of messing yourself up.” Alongside the treatment, she has removed alcohol from her diet and prioritized exercise, no matter how busy her schedule gets.
Alas, she still ended up with loose skin on her neck as a result of Winfrey’s weight loss transformation, from losing nearly 50 pounds with the help of said medication. For Winfrey and others, though, the pros will always outweigh the cons. Explaining how life-changing her weight loss has been, the TV host told People, “Everything is just calmer and stronger. … I hardly recognize the woman I’ve become.” She added, “But she’s a happy woman.”