Rosie O’Donnell’s Dramatic Weight Loss Sparks ‘Mounjaro Face’ Buzz: The Latest Celebrity Health Trend

Rapid weight loss often results in a noticeable decrease in facial fat, which can lead to sagging skin and a more drawn appearance. Rosie O’Donnell experienced this firsthand. In a photo from October 2025, signs of what is sometimes referred to as “Ozempic face” or, in her case, “Mounjaro face,” are evident. When compared to an image from September 2022, taken just before she began using the medication, the difference is apparent. The skin around her mouth and cheeks appears significantly looser.

The transformation is so pronounced that an expert described O’Donnell’s case as the most notable example of “Ozempic face” among celebrities, highlighting more than just the sagging skin. “Her skin has taken on a grayish tone,” Beverly Hills plastic surgeon Dr. Samuel Golpanian explained to us in August 2025. Despite these cosmetic changes, O’Donnell seems content with the trade-off, valuing the health benefits of her weight loss above all else.

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Rosie O’Donnell is thrilled with her weight-loss journey and frequently shares her enthusiasm. The comedian has faced health challenges for many years. In August 2012, she experienced a serious health scare with a heart attack. The following year, she opted for vertical gastric sleeve surgery to aid in her weight loss and health improvement. Over the next two years, she successfully shed 64 pounds, marking a significant milestone in her ongoing health journey.

Rosie O’Donnell is ecstatic about her weight-loss journey and can’t keep raving about it. The comedian has struggled with her health for decades. In August 2012, O’Donnell faced a tragic health scare when she suffered a heart attack. The following year, she underwent vertical gastric sleeve surgery to help her lose weight and improve her health. Within two years, she had dropped an impressive 64 pounds. 

The surgery helped curb O’Donnell’s appetite, especially her sweet tooth. “This year, the whole trick-or-treat, I had one lollipop. I don’t feel that same pull for it,” she told People in 2015. After getting on Mounjaro in 2022, her appetite decreased even further. While O’Donnell also implemented lifestyle changes to aid in her journey, like cutting back on sugar and exercising more, she attributed most of her weight-loss success to the GLP-1 drug. “My appetite has decreased significantly. It’s probably the meds,” she said in a January 2023 TikTok video.

O’Donnell hasn’t looked back. In the years since she got on Mounjaro, she has expressed shock at how different she looks. In August 2025, she revealed her struggles shopping for clothes because she has a hard time understanding her new body. “[Friends Camryn Manheim and Robin Ruzan] took this photo of me in the dressing room — i am shocked im a 12,” she shared on Instagram, referring to the picture seen above. She went on to share her appreciation for the weight-loss drug. “#mounjaro is a life saver,” she concluded her post.