Vanessa Williams recently opened up about her experience with transformative weight-loss medications.

In a conversation with Hello Magazine on Monday, January 12, the 62-year-old actress shared her journey with Mounjaro, a drug she has been using for two years. Describing it as a “game-changer,” Williams explained that the injectable medication, originally designed for Type-2 diabetes, also aids in weight loss. Reflecting on her milestone birthday, she stated, “Turning 60 made me contemplate longevity and looking my best. I asked myself, ‘What steps should I take?’”

Discussing the physical challenges she faced in her fifties, Williams revealed that her body underwent significant changes. “I began experiencing perimenopause in my late forties, but by 51, it was astonishing how much my body transformed,” she noted. “Despite maintaining my workout and diet routines, my body no longer responded as it once did, leaving me feeling out of control.”

To further enhance her well-being, Williams turned to Hormone Replacement Therapy, which alleviates menopause symptoms, and started NAD+ injections to boost cellular energy and combat aging. Praising the advancements in science, she exclaimed, “Science is truly remarkable. I’m eager to see what innovations come next!”

In related news, Serena Williams proudly showcased her 31-pound weight loss, attributing her success to the GLP-1 medication Ro. During an interview with People, published on Thursday, August 21, the 43-year-old former tennis champion expressed her satisfaction, stating, “I feel incredible—both physically and mentally lighter and healthier.”

When it comes to her physical appearance, Williams takes care of her skin by using a facial treatment called P5, courtesy of Dr. Sach Mohan. The treatment is an updated version of the viral vampire facial and uses hyaluronic acid to further hydrate the skin. (A vampire facial is when a patient gets their blood drawn and spun to separate platelet-rich fibrin and is then injected back into the face. It rejuvenates the skin, improves tone and texture, as well as fine lines and scars.)

“I’ve done it three times and definitely see a difference,” Williams said, noting that she also uses a Ziip device to help tighten and plump her face. “It was created by the makeup artist Melanie Simon, who I worked with when I was doing Desperate Housewives,” Williams shared. “She sent me one and I’ve been using it for 15 years.”

Another star who recently opened up about weight-loss medications is Serena Williams, who used GLP-1 to achieve her desired look and lose 31 pounds.

“I feel great,” she told People in August. “I feel really good and healthy. I feel light physically and light mentally.”

The tennis pro explained that after welcoming daughter Olympia in 2017, she was “never” able to reach the weight she “needed.” (Williams shares Olympia, now 8, and Adria, 2, with husband Alexis Ohanian.)

Rosie O’Donnell surprised fans in May 2025 by revealing a positive update on her weight loss journey — which she credited to using the medication Mounjaro. The injectable drug (also known as tirzepatide) is similar to Ozempic and Wegovy in that it is used primarily to treat diabetes, but can also be effective in weight […]

“It was crazy because I’d never been in a place like that in my life where I worked so hard, ate so healthy and could never get down to where I needed to be at,” Serena shared. “I had never taken shortcuts in my career and always worked really hard. I know what it takes to be the best.”

She added, “The size I was before, there was nothing wrong with it. It’s just not what I wanted to have. I just knew that I wanted to be where I personally felt comfortable.”