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In the third season, Burke left Cristina at the altar and vanished, later achieving a Harper Avery award and eventually relocating to Zurich, Switzerland, to establish a cutting-edge hospital. He settled down with a family and in the tenth season, extended an offer to Cristina to take over his hospital as he prepared for retirement.
Isaiah Washington exited the series amid reports that he had used a homophobic slur against costar T.R. Knight during a heated exchange with Patrick Dempsey. His attempts to defend himself only worsened the situation, leading to his dismissal. However, reconciliation with ABC allowed him to make a brief return in 2014.
Reflecting on the incident, Washington later issued a public apology, acknowledging, “I can also no longer deny to myself that there are issues I obviously need to examine within my own soul, and I’ve asked for help.”
After leaving Grey’s Anatomy, Washington portrayed Thelonious Jaha on The CW’s The 100 until his character’s demise in the fifth season, followed by a role in Starz’s highly praised P-Valley.