Real Madrid missed the chance to reclaim the top spot in La Liga after suffering a 2-1 defeat to Real Betis at the Benito Villamarín.

Los Blancos started brightly, taking the lead in the 10th minute through Brahim Diaz, who finished off a well-worked move involving Kylian Mbappe and Ferland Mendy.

However, Betis responded before halftime as Johnny Cardoso headed home from Isco’s corner for his first goal of the season.

The hosts dominated with 18 shots to Real Madrid’s eight and earned a decisive penalty early in the second half.

Jesus Rodriguez broke into the box before being brought down by Antonio Rudiger, allowing Isco to convert from 12 yards despite Thibaut Courtois getting close to the save.

Cucho Hernandez nearly sealed the win with a late chance but sent his effort wide after being set up by Antony.

However, Manuel Pellegrini’s side held firm, securing a long-awaited victory over his former club on his 10th attempt as Betis manager.

The defeat keeps Real Madrid second in the standings, with Atletico Madrid and Barcelona having opportunities to increase the gap in the title race this weekend.