The FDA has made a groundbreaking decision by expanding the approval of Addyi (flibanserin) to include women over the age of 50, encompassing those who are postmenopausal. This significant advancement in women’s sexual health offers a medical option for older women experiencing Hypoactive Sexual Desire Disorder (HSDD), a condition characterized by persistently low sexual desire causing distress. After years of rigorous research, debate, and advocacy, this approval marks a pivotal moment for addressing the sexual health needs of older women.

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What Is the Addyi Pill, and Who Is It For?

Addyi, a prescription drug initially approved for premenopausal women, is now sanctioned for use in postmenopausal women. Alyssa Dweck, MS MD, the Chief Medical Officer of Bonafide Health, clarifies that HSDD involves a persistent lack of sexual desire that leads to distress and is not attributed to other identifiable causes. With the FDA’s new approval for 2025, women over 50—who often face obstacles related to sexual desire due to menopause and hormonal changes—now have access to this treatment option.

Why Menopausal Women May Benefit Most

Menopause is known to cause significant hormonal changes that can lead to decreased libido and reduced sexual satisfaction, impacting relationships and self-esteem for many women. Addyi aims to offer a solution for those whose low sexual desire is not due to medical conditions, medications, or relationship issues. “Many women find that their libido is intricately linked to their identity, mental health, and relationship well-being,” notes Uma Darji, MD, a family medicine practitioner. Clinical trials have demonstrated that women over 50 using Addyi experienced modest but notable increases in sexual desire and satisfaction, especially when paired with counseling or lifestyle adjustments.

How the Addyi Pill Works and How It Differs from Viagra

In contrast to Viagra, which enhances blood flow to address erectile dysfunction, Addyi operates by influencing brain chemistry. It targets neurotransmitters such as dopamine, serotonin, and norepinephrine, which are crucial for mood and sexual desire regulation. Unlike Viagra, which is taken as needed, Addyi is administered daily, with its effects gradually manifesting over several weeks. This method focuses on the psychological and emotional components of sexual desire, rather than just the physical aspects.

What Can the Addyi Pill Do?

Though not a “magic bullet,” Addyi has been shown in studies to help women with HSDD experience more frequent and satisfying sexual events. Clinical trials indicate that women taking Addyi reported approximately 1–2 additional satisfying sexual experiences per month compared to those taking a placebo. “Through the years, I have occasionally prescribed Addyi and observed some positive responses,” shares Janette Gray, MD, an internal medicine physician and author of The Truth about Sex Hormones. While results can vary, many users find that the medication helps them feel more connected with their partners and enhances their sexual confidence.

Women’s Early Reviews of the Addyi Pill

Early user reviews are mixed but generally positive. One 43-year-old user, posting on Reddit, shared, “I’ve been on Addyi for several months. At first, it was just a really good sleeping pill. After consistent use—about a month—I started craving sex. During the day, night, whenever. I now have intense [orgasms] every single time. I want sex more.” Many women report that it takes time to work—usually around two months—but once it does, they notice improvements in desire and intimacy. “It’s been slow but steady for me,” one reviewer said. “I feel more connected, less frustrated with myself. Huge relief!”.​

Addyi Pill Side Effects to Watch For

Like any medication, Addyi comes with potential side effects. The most common include drowsiness, fatigue, nausea, dizziness, and low blood pressure. In rare cases, it can cause fainting, especially when combined with alcohol or certain medications. The FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for Addyi, meaning patients must be educated about these risks before starting treatment.​

Is Addyi Covered by Insurance?

Coverage for Addyi varies by plan. Many Medicare Part D plans and private insurers cover it, but patients may face copays or deductibles. As of 2025, the average monthly cost for Addyi is around $47 with insurance, but prices can fluctuate. Patients should check with their provider for specific details.​

Why It Took So Long to Get ‘Female Viagra’ Approved

Addyi’s journey to approval was long and controversial. The FDA rejected it twice before finally approving it in 2015 for premenopausal women, citing modest effectiveness and safety concerns. The expansion to postmenopausal women in 2025 reflects growing recognition of women’s sexual health needs and advances in research. Advocacy groups like Even the Score played a key role in pushing for approval, framing the lack of options as a women’s rights issue.​

Why the First Women’s Libido Pill Is So Historic

The approval of Addyi for women over 50 is historic because it acknowledges that sexual health is an important aspect of overall well-being, especially for older women. For decades, most research and treatments focused on men, leaving women with few options. Addyi’s approval signals a shift toward greater equality in sexual health care.​

Other Ways to Treat Low Libido

While Addyi is a new option, it’s not the only one. Lifestyle changes, counseling, hormone therapy, and relationship support can also help. Some women find that exercise, stress reduction, and open communication with their partners make a big difference. Others benefit from testosterone therapy or other medications, depending on their specific needs.​

The Bottom Line on ‘Pink Viagra’

Addyi represents a significant step forward for women’s sexual health, especially for those over 50. While it’s not a miracle cure, it offers hope and relief for many women struggling with low desire. As with any medication, it’s important to weigh the benefits and risks and work closely with a healthcare provider. For women seeking a boost in sexual desire, Addyi is now a viable option—and a symbol of progress in women’s health.