There are some side effects to consider when taking Ozempic or similar GLP-1 weight loss drugs. Karli Sine, a social media influencer who lost over 55 pounds on Semaglutide, now “microdoses Tirzepatide.” In a recent social media post, she discusses one of the top side effects of the drug and offers advice on how to address it – particularly focusing on fatigue.

What’s Happening and Why?

According to Sine, fatigue when using GLP-1s can stem from several factors. First, the body may be adjusting to consuming fewer calories without realizing it, leading to a decrease in energy intake. Secondly, blood sugar levels may drop lower than usual, especially for individuals accustomed to carb-heavy meals, resulting in a feeling of sluggishness. Lastly, lack of hydration and electrolyte imbalance can exacerbate fatigue, making simple tasks feel more tiring.

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Fatigue Is Temporary

Sine emphasizes that fatigue is a common experience as the body adapts to the new metabolic changes brought on by the medication. She reassures individuals that this fatigue is typically temporary and part of the body’s adjustment process to a new metabolic rhythm.

How long does fatigue last? “It’s most common in the first 2–4 weeks, but can pop up again if your dose increases or if you’re under-eating,” she says.

How to Ease Fatigue

Here are her tips for easing fatigue:

• Eat small, frequent meals!! Even if you don’t feel hungry
• Include protein and healthy fats to stabilize energy
• Add electrolytes (I LOVE the sugar free Liquid IV, coconut water, or unflavored salt + lemon water)
• Get outside and move. Even light activity boosts energy
• Make sure your iron and B12 levels are good (especially if you feel wiped)

Fatigue Is Normal

“You are losing a significant amount of weight (especially quickly) And that alone can trigger fatigue. You’re also burning through fat stores, shifting hormones, and possibly losing electrolytes, all of which can make your energy dip,” she says. “Even if you’re doing everything ‘right,’ your body may hit temporary low-energy phases as it adjusts to this new normal. Think of it like your system recalibrating, your energy will likely return (and even increase!) as your body settles into its healthier set point.”