TAMPA, Fla. (AP) — Baker Mayfield’s heroics came early in the fourth quarter instead of the final minutes.

Mayfield threw two touchdown passes and had a spectacular scramble to help the Tampa Bay Buccaneers beat the San Francisco 49ers 30-19 on Sunday.

After winning four games with scores in the last minute, the Buccaneers (5-1) didn’t need a late comeback.

Up 20-19 early in the fourth, the Buccaneers faced a third-and-14 at their 41. Mayfield ducked away from a sack in the pocket, escaped another defender, scrambled out of trouble, eluded more tackles and dove headfirst, stretching the ball to get a first down on third-and-14.

A few plays later, Mayfield connected with Tez Johnson on a 45-yard TD pass down the middle to give the 49ers a 27-19 lead. Johnson made an outstretched leaping catch and the rookie celebrated his first career TD with an acrobatic flip.

The 49ers were driving for a potential tying score when Mac Jones threw an interception to Jamel Dean on fourth-and-5 from the Buccaneers 33 with just under six minutes left.

The turnover led to Chase McLaughlin’s 45-yard field goal that extended the lead to 30-19.

Playing through knee and oblique injuries, Jones threw for 347 yards with two picks, losing for the first time in four starts filling in for Brock Purdy.

The injury-riddled 49ers (4-2) lost four-time All-Pro linebacker Fred Warner to a serious right ankle injury in the first quarter. Warner’s ankle appeared to turn sideways after a couple of players fell into him.

Everyone on the 49ers bench came onto the field to see Warner before he left the field with an air cast on his ankle.

San Francisco already was missing star edge rusher Nick Bosa, All-Pro tight end George Kittle, and wide receivers Brandon Aiyuk and Ricky Pearsall, along with Purdy and others.

The Buccaneers, who were missing star receivers Mike Evans and Chris Godwin and running back Bucky Irving, lost rookie receiver Emeka Egbuka to a hamstring injury in the second half.

Mayfield — who finished 17 of 23 for 256 yards — connected with a wide-open Kameron Johnson for a 34-yard TD to extend Tampa Bay’s lead to 20-13 late in the first half. It was Johnson’s first career reception. The Bucs went for the 2-point conversion following a roughing-the-passer penalty on the scoring pass but Rachaad White was stopped on a run.

Sean Tucker’s 9-yard TD run put the Buccaneers ahead 14-10 in the second quarter. Mayfield connected with Egbuka for 17 yards and Cade Otton for 23 on consecutive plays during the drive.

Christian McCaffrey ran in from the 1 to give the 49ers a 10-7 lead. It was San Francisco’s first rushing TD of the season on the team’s 148th carry.

Kindle Vildor set up Tampa Bay’s first score with an interception at the 49ers 25 that could have been a pick-6, but he stumbled twice before getting tackled at the 12.

White ran in from the 2 to put the Buccaneers up 7-0.

The Niners’ Eddy Pineiro kicked field goals of 52, 54, 42 and 29 yards.

Containing Christian

McCaffrey had 54 yards rushing on 17 carries and seven catches for 57 yards. He entered the game on pace for 133 receptions.

Injury report

49ers: Purdy (toe) missed his fourth game and Pearsall (knee) sat out his second in a row.

Buccaneers: Evans (hamstring), Godwin (fibula), RBs Bucky Irving (foot/shoulder) and Josh Williams (concussion), CBs Benjamin Morrison (hamstring) and Zyon McCollum (thumb) were inactive. … Egbuka had two catches for 24 yards before going down. … RG Luke Haggard (shoulder) left in the fourth quarter.

Up next

49ers: Host the Atlanta Falcons next Sunday night.

Buccaneers: Visit the Detroit Lions next Monday night.