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Seth MacFarlane and Mila Kunis are indeed close friends, as Digital Spy reported in 2012. Kunis said that her running friendship with one of her earliest mentors in show business has not faded throughout the years, which numbered over a decade at the time of the interview. “I don’t know what it’s like to not have Seth MacFarlane in my life,” Kunis said. “I’ve known Seth since I was 15, so 13 years.”
Kunis described the “Family Guy” showrunner as a close companion with whom she’s built a tight rapport. “Seth is great. Seth is one of my dearest friends. Seth and I have an incredible shorthand in our private life and in our working relationship.” The “Luckiest Girl Alive” star finished her praise of MacFarlane by reaffirming their friendship. “I consider him one of my closest, dearest friends,” Kunis said. “I really do.”
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In 2019, Kunis was present for MacFarlane’s induction into the Hollywood Walk of Fame, where she praised the showrunner’s unique comedic voice and called him a defining element of our generation. However, she was quick to fill her speech with good-natured ribbing of the variety only found between close friends.