Choosing Helberg over Jim Parsons, Bialik’s on-screen partner Sheldon Cooper, might seem surprising; however, she crafted Nathan’s role with Helberg in mind. In an interview with Variety, Bialik shared her deep connection with Helberg, noting, “It was very, very special to work with Simon; I basically wrote with him in mind, but I never thought he would do this movie. It also was very important to have someone who knew me when my father passed away, who knew my family, and it felt like having a friend there.” Helberg’s performance was well-received, contributing to the film’s 81% rating on Rotten Tomatoes.

Maintaining professional ties with her former co-stars, Bialik joined Melissa Rauch in 2025 for the final season of the “Night Court” reboot. In the episode “Mayim Worst Enemy,” Bialik played herself alongside Rauch, who portrayed Judge Abby Stone. Abby, a fan of Bialik’s ’90s sitcom “Blossom,” finds herself in a quirky plot where she suspects Bialik is plotting against her. This storyline mirrored real life as Rauch, a “Blossom” fan in her youth, once hesitated to confess her admiration when Bialik joined “The Big Bang Theory.” Speaking with People, Rauch reflected on this amusing dilemma, revealing how her childhood affection for “Blossom” eventually became a shared joke between the two.

Simon Helberg isn’t the only former “The Big Bang Theory” star that Mayim Bialik has kept close professional ties with. In 2025, she appeared alongside Melissa Rauch in the third and final season of the “Night Court” reboot, playing herself in the episode “Mayim Worst Enemy.” Rauch, who played Bernadette Rostenkowski in “The Big Bang Theory,” stars as Judge Abby Stone, a magistrate who does the night shift at Manhattan Criminal Court. Abby is a fan of Bialik thanks to her ’90s sitcom “Blossom” (which won’t be getting a modern-day reboot) and is excited to meet her, but she becomes paranoid that her new friend has lost her mind and may be trying to kill her.

Interestingly, the inspiration for the storyline came from real life, with Rauch having been a huge fan of “Blossom” growing up. Speaking to People, Rauch recalled how she wrestled with telling Bialik about her love of “Blossom” when the latter joined the cast of “The Big Bang Theory” as Amy Farrah Fowler. “I was in this dilemma of, ‘Do I let her know now that I am a super fan?’ I have pictures of me as Blossom for Halloween as a kid, I knew the whole dance.” When she did eventually tell Bialik, she was “so kind and gracious,” Rauch said. The pair remain close friends to this day.

Bialik has also continued to work with Jim Parsons. Not only do they sometimes spend time together off-screen, with Bialik attending Parsons’ wedding, he co-executive produced her Fox sitcom “Call Me Kat.” On top of that, they appeared together as Sheldon and Amy in the series finale of “Young Sheldon.” If you missed it and you want to know what happened to them, here’s how Amy and Sheldon’s lives have changed since “The Big Bang Theory.”