In “Avengers: Endgame,” Thanos tells the heroes who track him down that his final act with the Stones was to use them to destroy them, which is how the Avengers detected the Stones’ power signature during their desperate hunt for the Mad Titan. This means that the Soul Stone was annihilated, suggesting that Soulworld likely was as well, though this theory remains unconfirmed. The Soul Stone was seen again, sitting in a drawer in the Time Variance Authority, where TVA agents use them as paperweights, as they have no power there.

In the comics, the fate of the Soul Gem is considerably more detailed, as it has been wielded multiple times throughout its existence. It’s been used by Iron Man, the High Evolutionary, Adam Warlock, the Gardener, the In-Betweener, Nebula, Doctor Strange, Magus, Ultron, Hank Pym, Loki, Requiem, and, most recently, Multitude. It’s nearly impossible to destroy the cosmic artifacts in the comics, making Thanos’ destruction of their MCU counterpart unique and unexpected.

The Gems cannot be used to destroy themselves, but there was one instance where they were accidentally shattered. During an incursion from another dimension, the Illuminati assemble the Infinity Gems, but when Captain America uses the Infinity Gauntlet to push an entire universe away from Earth-616, the primary Marvel Comics universe, the Time Gem disappears, and the rest shatter, including the Soul Gem. This didn’t last long, though, as Doctor Doom found replacements from other realities. Eventually, each Gem was fused with a person from Earth, including the Soul Gem, which currently resides with Multitude.