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There have been multiple occasions where a star’s personal health struggles have been woven into their on-screen roles.
Jamie-Lynn Sigler revealed in 2016 that she had been living with multiple sclerosis (MS) since the age of 20. MS is a debilitating autoimmune disorder that attacks the nerve cells in the brain and spinal cord. A decade later, in January 2026, Sigler took on the role of a doctor facing the same illness on the popular show Grey’s Anatomy.
Sigler is not alone in bringing her real-life health battles to the screen. Other celebrities, like Michael J. Fox and Eric Dane, have also portrayed characters dealing with their own medical conditions.
Sigler isn’t the only celebrity who has done this as Michael J. Fox, Eric Dane and more portrayed TV characters battling their respective conditions.
Keep scrolling to see which stars’ real-life health issues became TV storylines: