AT LEAST two people have died in a terrifying plane crash after the aircraft smashed into a packed warehouse before exploding.

Harrowing footage shows the deadly collision as a giant fireball erupts after the small plane ripped through the building in California.

Another 19 people were left injured with at least 10 being rushed to hospital, according the Fullerton Police Department.

Others received emergency care just outside the warehouse which sat just six miles away from Disneyland.

Aerial images of the destroyed building show how a giant hole had been created after the plane tore through the roof,

Debris from the charred wreckage can also be seen sat inside.

Footage shows the moment the plane lost control and hit the warehouse as it flew in almost on its side.

As it hit a giant inferno ripped through the building as plumes of black smoke billowed into the air following the fireball blast.

The four seat, single-engine Van’s RV-10 crashed at around 14:15PST on Thursday, according to the Federal Aviation Administration.

Police quickly evacuated the building as several fire crews arrived to extinguish the flames and rescue those still trapped inside.

The building hit is believed to be the Michael Nicholas Designs furniture factory near the Fullerton Municipal Airport, according to the Orange County Register.

It is still unclear if those who died were employees at the company or in the aircraft.

In a post on X, congressman Lou Correa confirmed that at least a dozen of the hospitalised victims had been working in the factory.

Around 100 workers were ultimately evacuated.

Terrified witness Mark Anderson told KRCA-TV: “People are just shaken over the situation.

“It was just a large boom, and then one of the people went out and said, ‘Oh my gosh, the building’s on fire.'”

The plane appears to have been heading back towards the nearby airport shortly after it had taken off, according to KRCA-TV.

It was in the air for just under two minutes, according to flight-tracking website FlightAware.

Investigations are ongoing into what could have caused the fatal crash.

Just a few months ago, the Orange County area was again struck by a terrifying plane crash.

On November 25, a small aircraft smashed into a tree just one block away from the warehouse.

No fatalities were recorded.