KEEFE D could be a victim of a revenge attack from inmates over his self-confessed role in the killing of Tupac Shakur 27 years ago.

The one-time Compton drug dealer and gangster has also been fighting cancer, which he’s claimed in the past may be terminal.

Keefe faces such danger in Las Vegas prisons that he will be placed in protective custody cells, believes former Los Angeles gang enforcer James McDonald.

McDonald, who knew Keefe from their Los Angeles neighborhood wars, is adamant that the 60-year-old has a “problem” both waiting for him in the trial and should he be convicted.

Keefe, real name Duane Davis, will be arraigned for the murder of Shakur at the Las Vegas courts on Thursday morning. His lawyer has said he plans to plead not guilty.

McDonald, who was known as Mob James during his days as security detail for Death Row Records, exclusively said on camera: “As soon as he touched down in a prison…you got people that were fans of Tupac, they’re going to come at him, they’re going to have to put him in protective custody because he ain’t going to walk no mainline.

“That’s impossible. He won’t last a year.

“So with him saying it (his role in Tupac’s killing), and some of the guys I know from the motorcycle set, this man is telling everybody he did it. I wish I knew where he lived.

“The people in prison is going to try to do something to him just because it was Tupac – not just you just killed a random gang member. But because it was Tupac.

“And he’s going to have to live with that for his days in prison.

“Ain’t no if, ands, or buts ain’t, ain’t nobody not going to touch him. Guaranteed he’s going to have a problem.”

Last week as former Southside Crip Keefe D’s acting lawyer Ross Goodman confirmed to The U.S Sun that his client had battled colon cancer.

When probed about Keefe’s cancer battle, Goodman confirmed to The U.S. Sun: “I heard the same thing.”

He added: “I haven’t reviewed any medical records yet, but apparently he did have colon cancer shortly before he gave those statements (media interviews confessing to being a part of Tupac’s murder).”

Respected Vegas attorney Goodman, renowned for handling significant criminal cases in Nevada, feels Keefe remains upbeat.

Associates of Keefe claimed that he had told friends he “was not expecting to live long” before he wrote his memoir Compton Street Legend, which featured his confessions about his role in Tupac’s death.

McDonald, who was known as Mob James while working as Suge Knight’s security chief in the late 1980s and 1990s, says the 60-year-old former drug dealer talked about Tupac’s death, believing he could die before any criminal probe.

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But after fighting off the condition. Keefe boasted that he survived, against the odds, as “God got me.”

Speaking exclusively on camera, McDonald told The U.S. Sun: “Well, I think everybody knows he has got cancer.”

Keefe has spent several years boasting about his criminal life and involvement in the murder of Shakur in September 1997.

He outlined how he and other gangsters hunted down ‘Pac close to the Las Vegas strip after his nephew Orlando Anderson was beaten by the rapper.

McDonald says Keefe regrets his decision to brag and boast “for a few thousand dollars” and bolster his ego.

“He is 60, so if they give him 30 (years for murder), it’s over.

“No grandchildren. No time with your kids. You have left your wife, the whole nine. I say everybody should think about what the f***k they doing out there.

“I have a lot of regrets about my past history. And I’m one to honestly say if I can go back to when I was 13 or 14, I would go back and be totally different.

“I would change everything that I ever done.

“Keefe D is me – without a mouth, though. Keefe D is every gang member, every everybody, that’s out there that’s living that life, you know, I’m saying they just not that stupid.

McDonald now works to help youngsters stay away from street violence and gang communities across California and the US.

He raises those issues on his hit podcast Still Bombing.

“All the Tupac fans and everybody should pay attention to what’s happening here; that we lived a f***d -up life, and we put ourselves in situations, and then we cry wolf.

“Take heed. This s**t ain’t fun you get nothing out of it the outcome is always bad.

“I don’t care what you do, how you do it. it’s gonna be bad, so think about the consequences.

“There are consequences to every action, and we just got to pay attention but be productive in life, man that’s all I say be productive in life and stay away from those that want a gang bang, those that want to influence you and to live in a life you don’t want to live. Stay away from it.

“Love your mom and your daddy, your brothers, and sisters, because if I would have did that, my brother would have still been here, and I would have had all of his grandkids we’d have been together we have been doing everything, but I lost. I lost living that life.

“I lost a lot, so I just say everybody use your mind think it ain’t always good, especially being a game, especially taking life for free the price is a mother f****r.”