Tragedy struck in an Arizona parking lot on Saturday afternoon, resulting in the death of one man and injuries to three others, including two children, following a shooting incident.

The altercation, which involved a sedan and an SUV, unfolded around 2:45 p.m. in a commercial parking area in southern Phoenix.

During a press briefing, Sgt. Brian Bower of the Phoenix Police Department (PPD) explained that the incident began as a disagreement between the occupants of the two vehicles, which escalated as they entered the parking lot.

The confrontation intensified into a physical altercation, leading to gunfire, Bower reported.

In response to the shooting, police tape cordoned off the vicinity near 19th Ave. and Baseline in Phoenix, where officers were actively investigating the scene. (Phoenix Police via X)

The male suspect was alone in the sedan, Bower said. A man, woman and two children were in the SUV.

Police said multiple rounds were fired and all four people in the SUV were shot.

Police have not yet said what led up to the Phoenix shooting. (Phoenix Police Department)

The man in the SUV died at the scene, according to Bower. The woman and two children who were also in the SUV were taken to the hospital and remain in critical condition.

Bower said the suspect, who has not yet been publicly identified, remained at the scene until police arrived. The man was also treated at the hospital and later taken into custody.

It is unclear what led to the shooting, which left one person dead and three others wounded. (iStock)

Police did not confirm any pending charges against the suspect, noting he was speaking with detectives.

Detectives have not yet ruled out the possibility of the incident being related to road rage or self-defense, as there is no indication the two parties knew each other, according to Bower.

The PPD did not immediately respond to additional inquiries from Fox News Digital.

This is a developing story. Please check back for updates.