The Late Late Low.

During the star-studded Breakthrough Prize gala in Los Angeles on Saturday, James Corden shocked the audience with an awkward sex joke about Dame Judi Dench.

“Tonight is the one night that Hollywood and science come together, other than of course that one magical evening where Dr. [Anthony] Fauci had a one-night stand with Dame Judi Dench,” the British comedian said onstage.

The one-liner was met with awkward silence from the room as the camera cut to Olivia Wilde who appeared shocked, per the Daily Mail.

Reps for Corden, 46, and Dench, 90, did not immediately respond to Page Six’s requests for comment.

Attendees at the Breakthrough Prize ceremony included Gwyneth Paltrow, Kate Hudson, Drew Barrymore, Lizzo, Christina Aguilera, Paris Hilton, Bill Gates and Mark Zuckerberg.

Jeff Bezos and his fiancée, Lauren Sánchez, also made an appearance at the event, along with Katy Perry and Gayle King, ahead of Blue Origin’s all-female space flight with the trio on April 14.

Meanwhile, Corden previously came under fire for making jokes about Harvey Weinstein’s sexual assault allegations while hosting the amfAR Gala Los Angeles in 2017.

“It’s a beautiful night here in LA. So beautiful, Harvey Weinstein has already asked tonight up to his hotel to give him a massage,” the former “Late Late Show” host said at the time.

“It has been weird this week though, watching Harvey Weinstein in hot water. Ask any of the women who watched him take a bath,” he continued to nervous groans from the audience.

Corden also said, “Harvey Weinstein wanted to come tonight, but sadly he’ll settle for whatever potted plant is closest.”

Rose McGowan, who accused Weinstein of rape, vehemently condemned the comedian for his jokes.

The “Cats” star apologized hours later, tweeting, “sexual assault is no laughing matter. I was not trying to make light of Harvey’s inexcusable behavior, but to shame him, the abuser, not the victims.

“I am truly sorry for anyone offended, that was never my intention.”