More than 100 firefighters are battling a massive blaze that caused multiple high-rise buildings to ignite in Baltimore’s city center Tuesday afternoon.

Baltimore City Fire Department (BCFD) officials confirmed the five-alarm fire is downtown near North Howard and West Fayette streets. As of 4:40 p.m., crews continued to attempt to contain the fire.

One building collapsed, and two four-story buildings ignited, according to officials. All three buildings are presumed to have been vacant, though crews have not entered because the structures are unstable.

Firefighters responded to a massive fire Tuesday in downtown Baltimore. (WBFF)

Nearby landmarks include the Hippodrome Theatre, CFG Bank Arena, and the University of Maryland’s Baltimore campus.

Baltimore Fire did not immediately respond to inquiries from Fox News Digital.