The conclave to select the next pope will begin on Wednesday, May 7, according to the Vatican. 

The date was confirmed Monday by papal spokesman Matteo Bruni following the April 21 death of Pope Francis. 

The Vatican also announced “the Sistine Chapel will be closed to the public from Monday 28 April 2025 for the requirements of the Conclave.”

An estimated 200,000 people attended a special Mass at St. Peter’s Basilica on Sunday by Cardinal Pietro Parolin, the Vatican’s secretary of state.  

Cardinals arrive to pay their respects to the grave of the late Pope Francis inside St. Mary Major Basilica in Rome, on Sunday, April 27. (AP/Bernat Armangue)

A conclave, organized by the camerlengo, presently Cardinal Kevin Ferrell, begins 15 to 20 days after the pope’s death. 

“Anything could happen,” Tim Gabrielli, associate professor and the Gudorf chair in Catholic intellectual traditions at the University of Dayton in Ohio, told Fox News Digital. 

During a conclave, cardinals vote through a secret ballot. A two-thirds majority is required for the election. After each round of submissions, ballots are read aloud and then burned. The ashes are used to notify audiences around the world and onlookers in St. Peter’s Square of the election’s status. 

People attend a mass presided over by Vatican Secretary of State Cardinal Pietro Parolin on the second of nine days of mourning for the late Pope Francis in St. Peter’s Square, at the Vatican, on Sunday, April 27.  (AP/Andreea Alexandru)

Black smoke from the Sistine Chapel at the Vatican indicates a new round of voting is set to happen. White smoke signals a new leader of the Roman Catholic Church is selected. 

Fox News’ Danielle Wallace, Gabriele Regalbuto, Courtney Walsh-Annesi and the Associated Press contributed to this report.