A week after Israel launched a surprise attack on Iran aiming to wipe out its nuclear program, all eyes are now on the country’s reclusive supreme leader, Ayatollah Ali Khamenei.

On Thursday, following an Iranian missile strike that hit an Israeli hospital, Israel Defense Minister Israel Katz said in a statement that “Khamenei will be held accountable for his crimes,” adding during a visit to one of the impact sites that “a person like that should not exist,” later calling him “the modern day Hitler,” according to the Times of Israel.

Over decades of rule, Khamenei has built an impenetrable circle around him both inside and outside of Iran. Now, with Israel taking out some of his closest aides and senior security figures, as well as significantly weakening its militant Islamic allies across the region, the supreme leader is beginning to look increasingly isolated.