The National Transportation Safety Board (NTSB) has confirmed that the left engine of a UPS cargo plane detached during takeoff, contributing to a fiery crash at Louisville Muhammad Ali International Airport in Kentucky on Tuesday.

UPS Flight 2976 crashed shortly after departing the airport around 5:15 p.m. ET, carrying three crew members and over 200,000 pounds of fuel. The aircraft collided with the Kentucky Petroleum Recycling building, according to a statement made by Governor Andy Beshear.

The tragic incident resulted in at least 11 fatalities, including the three crew members aboard the plane and a young child. Additionally, 11 individuals on the ground sustained injuries, Governor Beshear reported.

While the investigation into the crash’s cause is ongoing, NTSB officials have noted that the left engine’s detachment was significant. The engine was subsequently discovered on the airfield.

Surveillance footage from a local Kentucky business captured the moment the wide-body UPS cargo plane went down on November 4, 2025. The footage provides a stark visualization of the disaster.

Preliminary information indicates the flight was not delayed, and no immediate maintenance work was performed before takeoff, officials said. There are no known airworthiness directives tied to the aircraft or its engines.

The NTSB confirmed the FBI is assisting with the investigation “under a longstanding Interagency agreement.”

It is unclear if criminal intent was suspected, or what the plane was carrying at the time of the crash.

NTSB officials said shipments that travel through the Louisville UPS hub daily contain “life-saving drugs, postal products, food, supplements, you name it.”

A fireball erupts near airport property after a UPS plane crashed at Louisville International Airport Tuesday, Nov. 4, 2025. (Jon Cherry/AP Photo)

Investigators on Wednesday afternoon recovered the aircraft’s cockpit voice recorder and flight data recorder — commonly known as the “black box” — which the NTSB said suffered heat exposure but appeared intact.

They will be analyzed at the NTSB’s lab in Washington, D.C.

Several specialized groups have been established by the NTSB, including: an operations group to review the flight history and crew duties leading up to the crash; a structures group to document the wreckage, impact angles and aircraft trajectory before impact; a powerplants group to examine the engines and related accessories; a systems group to investigate hydraulics, electrical, instruments and flight controls; and a maintenance group to review maintenance records and history of work performed on the aircraft.

Smoke rises from the site of a UPS cargo plane crash near the UPS Worldport at Louisville Muhammad Ali International Airport in Louisville, Ky., Nov. 4, 2025. (Leandro Lozada/AFP via Getty Images)

Federal Aviation Administration (FAA) records showed the plane was in service for nearly 35 years, according to a report from Reuters.

The agency said it is balancing investigative thoroughness with the need to reopen runways at the airport, which it said is critical for essential supply chain operations.

The Louisville airport is home to UPS Worldport, a global hub for the shipping company’s air cargo operations and its largest package-handling facility worldwide. UPS is the largest employer in Louisville, providing 26,000 jobs, according to the publication Louisville Business First.

Fire and smoke mark where a UPS cargo plane crashed near Louisville Muhammad Ali International Airport Nov. 4, 2025. (Stephen Cohen/Getty Images)

Beshear declared a state of emergency Wednesday morning to assist in recovery efforts, noting he expects the number of fatalities to rise to 12 by Wednesday night.

“Let’s continue to pray for their families and loved ones during this heartbreaking time,” he wrote in an X post.

The NTSB will hold an organizational meeting to establish party status for various entities including the aircraft manufacturer, operator, labor unions representing crew members, and relevant government agencies. Once they join, they are prohibited from commenting publicly without NTSB consent.

Officials noted the investigation will not be impacted by the ongoing federal government shutdown.

The FBI did not immediately respond to Fox News Digital’s request for comment.