Tom Hanks is in a league of his own.

The actor had an unusual experience at one of the most famous museums in the world when he ended up without pants in front of the Mona Lisa.

During the filming of “The Da Vinci Code” in 2006, a strange incident occurred involving Tom Hanks, who was 68 years old at that time. The amusing story was retold by Ron Howard before a crowd of strangers.

Ron Howard, aged 70, shared the humorous anecdote during a gathering reminiscent of “Happy Days” at MegaCon in Orlando on February 7, as reported by People magazine. He mentioned that all the filming equipment was stored in the room where the famous painting, the Mona Lisa, was displayed.

As the production crew rushed to stay on schedule while shooting at the Louvre in Paris, the set of “The Da Vinci Code” encountered a hilarious mishap according to Ron Howard’s account of the event.

Howard continued: “And Tom Hanks didn’t have time to go back to his dressing room to change for the next scene. And so I was giving him some notes about what the next scene was going to be and he was changing his pants in front of the Mona Lisa.”

The movie director said he’d never forget seeing the Oscar winner pantless in front of one of the world’s most admired art pieces.

“I said, ‘Wait a minute. This is a moment we have to remember,’” Howard laughed, noting his past work with Hanks has included some strange places. “We’ve been under the water with the mermaid, we’ve been weightless with Apollo 13, and now you’re pants-less with the Mona Lisa.”

Howard has worked with Hanks on five films, including “Splash” (1984), “Apollo 13 (1995) “The Da Vinci Code” (2006), Angels & Demons (2009) and “Inferno” (2016).

The Post reached out to Hanks’ rep for comment.

Hanks recently made headlines after his Pacific Palisades home was spared from the devastating Los Angeles fires that ravaged the city in January.

The Post obtained photos of the “Cast Away” actor’s clifftop mansion that he shares with his wife, Rita Wilson, unscathed from the blaze that wiped out over 6,837 structures and burned 23,448 acres over 24 days.

The Palisades Fire also took the lives of at least 12 people.

Many who lost their homes in the Palisades Fire are suing the city of LA and the LA Department of Water and Power for damages, including “The Hills” stars Spencer Pratt and Heidi Montag, whose $3 million property burned down in the blaze, claiming that the lack of water supply is largely responsible for their damages.