Iran warned that the United States joining forces with Israel would mean an “all-out war,” as Israel bombarded sites overnight that it says would have allowed Iran to continue enriching uranium, as well as attack Israeli forces.

“Any American intervention would be a recipe for an all-out war in the region,” Iranian Foreign Ministry spokesman Esmail Baghaei warned Wednesday during an interview with Al Jazeera English.

He did not elaborate, but thousands of American troops are based in nearby countries within range of Iran’s weapons. The U.S. has threatened a massive response to any attack.

Another Iranian official apparently ruled out demands for the country to give up its disputed nuclear program.

Israeli forces have struck over 1,100 different components across Iran as of the sixth day of the conflict, Defrin said.

He said IAF jets also struck several weapons and missile production sites in Tehran. On Wednesday morning, Israeli aircraft identified and struck five Iranian AH-1 attack helicopters located at Kermanshah airport.

“We have clear goals and objectives: removing the existential threat to the State of Israel, significantly impairing the nuclear program in all its components, and inflicting substantial damage to the missile array,” Defrin said. 

The IDF said it identified around thirty launches fired from Iran towards Israeli territory in two barrages Tuesday night. 

The Israeli Iron Dome air defense system fires to intercept missiles during an Iranian attack over Tel Aviv, Israel, early Wednesday, June 18, 2025.  (AP Photo/Leo Correa)

“Most of them were intercepted, and there were no casualties. I know these are complex days, but we cannot afford complacency,” Defrin said, warning Israelis to strictly adhere to home-front safety guidelines. 

Trump initially distanced himself from Israel’s surprise attack on Friday that triggered the conflict, but in recent days has hinted at greater American involvement, saying he wants something “much bigger” than a cease-fire. 

The U.S. has also been shifting assets to the Middle East, including sending more warplanes to the region.

Trump said in social media posts on Wednesday that the U.S. knows where Iran’s Supreme Leader is but would not kill him, for now. He also called for the “complete surrender” of Iran.

“We now have complete and total control of the skies over Iran,” Trump wrote. 

Fox News’ Stephanie Simon and the Associated Press contributed to this report.