In a significant development, U.S. and allied forces have successfully neutralized nearly 25 Islamic State operatives in Syria shortly after conducting a major strike on December 19. This recent operation, as highlighted in a new statement from U.S. Central Command (CENTCOM), reinforces the ongoing concern that ISIS continues to pose a substantial threat within the region.

Between December 20 and December 29, CENTCOM reported that U.S. and partner forces executed 11 subsequent missions. These operations resulted in the death of at least seven ISIS members, the capture of several others, and the destruction of four ISIS weapon caches. This series of actions followed the ambitious Operation Hawkeye Strike, a coordinated effort by U.S. and Jordanian forces that targeted over 70 ISIS sites in central Syria using more than 100 precision munitions, effectively dismantling infrastructure and weapons facilities associated with the extremist group.

Adm. Brad Cooper, the CENTCOM Commander, emphasized the U.S. commitment to continuing these efforts. “We will not relent,” he stated, affirming that American forces, in cooperation with regional partners, are determined to dismantle the ISIS networks that threaten both U.S. and regional security.

The extensive nature of these follow-up raids underscores a critical reality stressed by U.S. commanders and analysts: while ISIS may no longer control vast areas, its capacity to organize, launch attacks, and rebuild within Syria’s complex security environment remains intact.

In northeastern Syria, U.S. Army soldiers, as part of Task Force WARCLUB, continue to conduct patrols from remote combat outposts. These forces collaborate closely with the Kurdish-led Syrian Democratic Forces (SDF) to combat residual ISIS elements and deter pro-Iranian militias, maintaining a vigilant presence in the region. (Image: John Moore/Getty Images)

Syria remains divided among competing forces, militias and foreign-backed armed groups, with no single authority exercising full control over large parts of the country. Analysts say that vacuum continues to provide space for ISIS cells to operate quietly, recruit and exploit overstretched local forces.

Analysts note that Syria’s security environment remains shaped by former jihadist networks that were never fully demobilized after the war. The country’s transitional leadership, including President Ahmed al-Sharaa, emerged from armed Islamist factions that relied heavily on foreign fighters and militias, according to regional security assessments. While those groups are not synonymous with ISIS, experts say the incomplete dismantling of extremist networks has left gaps that ISIS cells continue to exploit.

“ISIS today doesn’t need a caliphate to be dangerous,” Bill Roggio told Fox News Digital. “We’ve always been quick to declare terrorist organizations defeated and insignificant, and that couldn’t be further from the truth.”

Roggio said the group has adapted rather than disappeared, shifting away from holding territory toward smaller, more covert cells capable of carrying out lethal attacks. He pointed to ongoing ISIS activity not only in Syria and Iraq, but also in Afghanistan and other regions, citing United Nations reporting that estimates roughly 2,000 ISIS fighters remain active in Afghanistan alone.

“That’s not what a defeated group looks like,” Roggio said, noting that ISIS continues to recruit, indoctrinate and inspire attacks even without the visibility it once had.

ISIS terrorists in Syria. (Reuters)

One of the most sensitive vulnerabilities remains the network of detention facilities in northeastern Syria holding thousands of ISIS terrorists and supporters. Those prisons are guarded primarily by Kurdish-led forces backed by a small U.S. military presence, estimated at roughly 1,000 troops, according to Reuters.

U.S. and coalition officials have repeatedly warned that any major disruption to prison security could allow hardened ISIS operatives to escape and reconstitute networks across Syria and beyond. Kurdish officials have also raised concerns about funding shortages, manpower strain and pressure from rival militias operating nearby.

While U.S. officials have not publicly linked the recent strikes to prison-related threats, analysts say the broader environment of fragmented control increases the risk of coordinated attacks, insider assistance or prison unrest.

The danger is not theoretical. ISIS has previously staged mass prison break operations in Syria and Iraq, including a 2022 assault on the al-Sinaa prison in Hasakah that required days of fighting to contain.

The U.S. strikes also come amid continued instability inside Syria, where multiple armed actors operate with overlapping authority. Analysts note that clashes among militias, sectarian violence and unresolved command structures have weakened overall security and diverted attention from counterterrorism efforts.

U.S. soldiers attached to the Iowa National Guard sign GBU-31 munitions systems in the U.S. Central Command area of responsibility Dec. 18, 2025 as the U.S. military launched large-scale strikes against dozens of Islamic State targets in Syria in retaliation for an attack on U.S. personnel, U.S. officials said. (Air Force Photo/Handout via Reuters)

Bombings in neighborhoods of Damascus, including Mezzeh, and unrest in minority areas have further illustrated the gaps ISIS and other extremist groups can exploit, according to regional security assessments and open-source reporting.

“Syria’s chaos is the accelerant,” Roggio said. “ISIS thrives where no one is fully in charge.”

U.S. officials and analysts stress that ISIS activity in Syria is part of a wider pattern rather than an isolated flare-up.

Sources in the Israeli Mossad told Fox News Digital of continued ISIS-linked activity across multiple theaters, including recruitment networks and small-scale attacks designed to test security responses and maintain operational relevance.

In Turkey, security forces recently clashed with Islamic State militants during counterterrorism operations, wounding several officers, according to Reuters on Monday. Turkish authorities said the raids targeted ISIS cells suspected of planning attacks inside the country.

Security forces loyal to the interim Syrian government ride in the back of a vehicle moving along a road in Syria’s western city of Latakia on March 9, 2025. Syria’s interim President Ahmed al-Sharaa called for national unity and peace on March 9, amid growing international backlash following the killing of civilians along the country’s coast in the worst violence since the overthrow of former president Bashar al-Assad. (Omar Haj Kadour/AFP via Getty Images)

“These are signals, not spikes,” Roggio said. “ISIS operates across regions, adapting to pressure and exploiting weak governance wherever it finds it.”

The renewed U.S. military action raises difficult questions for policymakers about how long the current containment strategy can hold.

While U.S. officials say the Dec. 19 strikes delivered a significant blow to ISIS infrastructure, they have also acknowledged that counterterrorism operations alone cannot eliminate the underlying conditions that allow the group to persist.

People wave guns in the air as they gather to celebrate the fall of the Syrian regime in Umayyad Square on Dec. 8 in Damascus, Syria. (Ali Haj Suleiman/Getty Images)

“Just because we want to declare the war against terror over doesn’t mean it’s over,” Roggio said. “The enemy gets a vote.”