ST. LOUIS (AP) Storm systems sweeping across the Midwest have left at least 16 dead, including nine people killed after a tornado sparked what authorities called a mass casualty event in southeastern Kentucky.

Kentucky authorities said there were also severe injuries when a twister tore across Laurel County late Friday.

“The search is continuing in the damaged area for survivors,” the office of Sheriff John Root said in a statement posted on social media. An emergency shelter was set up at a local high school and donations of food and other necessities were arriving.

“The outpouring from our community has been heartwarming. We are continuing to accept donations,” the Sheriff’s Office said.

Spokesman Gilbert Acciardo said rescuers have “been on the ground all night looking for possible survivors. That’s what we’re continuing to do.”

The tornado, which ripped across the largely rural area and extended to the London Corbin Airport, hit shortly before midnight.

“Lives have been changed forever here tonight. This is a time we come together, and we pray for this community,” London Mayor Randall Weddle told WKYT-TV. “I have never personally witnessed what I‘ve witnessed here tonight. There’s a lot of devastation.”

Missouri pounded by storms, with deaths confirmed in St. Louis

The storms were part of a weather system Friday that killed seven in Missouri and also spawned tornadoes in Wisconsin, left several hundred thousand customers without power in the Great Lakes region and brought a punishing heat wave to Texas.

St. Louis Mayor Cara Spencer confirmed five deaths in her city and said more than 5,000 homes were affected.

“This is truly, truly devastating,” Spencer said, adding that the city was in the process of declaring an emergency and an overnight curfew Friday had been put into place in the neighborhoods with the most damage.

The number of people injured was not immediately known. Barnes-Jewish Hospital received 20 to 30 patients from the storm with some in serious condition and most expected to be discharged by Friday night, according to hospital spokesperson Laura High.

St. Louis Children’s Hospital received 15 patients with two of them expected to remain in the hospital into the weekend, she said.

National Weather Service radar indicated a tornado touched down between 2:30 p.m. and 2:50 p.m. in Clayton, Missouri, in the St. Louis area. The apparent tornado touched down in the area of Forest Park, home to the St. Louis Zoo and the site of the 1904 World’s Fair and Olympic Games the same year.

At Centennial Christian Church, City of St. Louis Fire Department Battalion Chief William Pollihan told The Associated Press that three people had to be rescued after part of the church crumbled. One of those people died.

Stacy Clark said his mother-in-law Patricia Penelton died in the church. He described her as a very active church volunteer who had many roles, including being part of the choir.

Jeffrey Simmons Sr., who lives across from the church, heard an alert on his phone and then the lights went out.

“And next thing you know, a lot of noise, heavy wind,” he said. He and his brother went into the basement. Later, he realized it was worse than he thought. “Everything was tore up.”

Downed trees and stop lights also caused traffic gridlock during the Friday afternoon commute and officials urged people to stay home.

John Randle, a 19-year-old University of Missouri-St. Louis student, said he and his girlfriend were at the St. Louis Art Museum during the storm and were hustled into the basement with about 150 other people.

“You could see the doors flying open, tree branches flying by and people running,” he said. “A lot of people were caught outside.”

Christy Childs, a Saint Louis Zoo spokesperson, said in a text that the zoo would remain closed Saturday because of downed trees and other damage. Childs said all animals were safe and that there were no reports of significant injuries to staff, guests or animals.

“We can’t definitively say whether or not it was a tornado it likely was,” National Weather Service meteorologist Marshall Pfahler said.

A tornado struck in Scott County, about 130 miles (209 kilometers) south of St. Louis, killing two people, injuring several others and destroying multiple homes, Sheriff Derick Wheetley wrote on social media.

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Associated Press writers Haya Panjwani in Washington, D.C., Heather Hollingsworth in Kansas City, Missouri, and Lisa Baumann in Bellingham, Washington, contributed to this story.