Extreme winter weather is impacting tens of millions of Americans, with some East Coast cities experiencing the most significant snowfall in decades on Monday.

A cold front has covered a wide area from Kansas to Nebraska, Illinois, Indiana, and Ohio with snow and ice before moving eastward to the East Coast on Sunday night.

It blew into the Washington, DC, area with uncharacteristically heavy snowfall, more than 5.5 inches, that persisted through Monday.

Maryland, in particular, received heavy snowfall, with Annapolis getting around 7 inches of snow by Monday afternoon. This is the most snow the city has seen in a single day since it was hit with 16 inches back in 2000, as reported by Fox Weather.

Of course, the snowfall in Maryland would be considered a dusting in some areas such as upstate New York’s Oneida County, where the town of Lee Center got slammed with more than 6 feet of the white stuff since the weekened, according to the Utica Observer Dispatch.

But cities in Delaware and southern New Jersey joined Annapolis in seeing the most single-day accumulation in years, with upwards of 9 inches in some places.

New York City and the rest of the tri-state area were spared the brunt of the storm, with only about half an inch of snow falling in Central Park by midday and not much more accumulation expected later.

The sweeping storm conditions put more than 60 million Americans under winter weather advisories across their 2,100-mile path and led to blizzard conditions with high winds that left about 300,000 without power.

Roadways were left perilous across most of the storm’s path.

In Missouri, 600 cars were stranded in the snow over the weekend, while hundreds of accidents were reported across Indiana, Kansas, Kentucky, and Virginia.

Swaths of the interstate in Kansas — where more than 14 inches of snow fell — were shut down over the dangerous conditions as Gov. Andy Beshear declared a state of emergency Monday.

“We see far too many wrecks out there for people that do not have to be on the roads, so I want to ask: Stay inside,” Beshear said.

More than 1,400 flights were also cancelled across the country, and nearly 1,000 were delayed over the snows Monday.

At Ronald Reagan National Airport in DC, nearly two thirds of departures and nearly half of arrivals were cancelled.

And more snow could be on the way this weekend, Fox Weather meteorologists told The Post.

A storm system is expected to develop over Texas around Thursday, and then make its way northeast across the country — though it is still unclear whether it will head across the southern states or make its war more northward toward the New York area.

With Post wires