Roche moves antibiotic for superbug to Phase 3 of testing
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Swiss drugmaker Roche announced on Monday its plans to progress testing of an antibiotic designed to combat a common drug-resistant bacteria responsible for causing severe hospital infections into the final phase of testing on human subjects.


Vials of liquid on a white table and the logo of a large pharmaceutical company Roche. March 15, Barnaul, Russia.
Drugmaker Roche is advancing testing of an antibiotic against a common drug-resistant bacteria into the third and last phase of testing on humans. diy13 – stock.adobe.com

A new antibiotic (zosurabalpin, red) traps lipopolysaccharide (orange) in the intermembrane transporter of the Gram-negative bacterium Acinetobacter baylyi
The experimental antibiotic zosurabalpin was jointly developed with Harvard University. Juan Gärtner – stock.adobe.com

The company revealed that the experimental antibiotic, known as zosurabalpin and developed in collaboration with Harvard University, will undergo trials specifically targeting acinetobacter baumannii, leveraging a novel mechanism of action to which bacteria have not yet developed resistance.

Roche highlighted that drug-resistant strains of acinetobacter are widespread globally, posing a significant burden on hospitalized patients and leading to critical conditions such as pneumonia and sepsis.

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