Rosie O’Donnell shocked fans as she gave an update with her dramatic weight loss journey while using a popular weight-loss drug.

The 63-year-old TV personality, who experienced a significant setback and left the U.S. following Trump’s election win, showcased her slimmer figure on her main Instagram page while performing at a stand-up comedy show.

She has been open about taking Mounjaro and first revealed she was taking the drug back in 2023.

In the caption of the picture, the star penned to her followers: ‘i cant believe this is me now #mounjaro #weightloss #bodydismorphia.’

O’Donnell donned a donned a yellow sweater as well as a blouse underneath and blue pants in the snap.

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Rosie O’Donnell, 63, shocked fans as she gave an update with her dramatic weight loss journey while using a popular weight-loss drug

In the caption of the picture, the star penned to her followers: ‘i cant believe this is me now #mounjaro #weightloss #bodydismorphia’

Social media users jumped to the comment section to share their thoughts on Rosie’s weight loss. 

One wrote, ‘You look great Ro!!! I’m glad you’re feeling better and taking care of your health!’ 

One follower inquired about the amount of weight the celebrity has lost since starting Mounjaro and commented, ‘Fantastic! How much weight exactly? I’m on a similar path,’ to which O’Donnell responded, ‘I don’t know.’

The weight loss dug ‘is an injectable prescription medicine that is used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes mellitus,’ per the official website. 

‘You look amazing! I’ve lost 110 on Mounjaro. My A1C is in check. Blood sugar normal,’ a fan also shared. 

Another penned, ‘Good for you, Rosie!!!! Shine ON!’ and one added, ‘Looking great. And look at you doing stand up in Ireland. Literally back to your roots.’ 

Back in March of this year, O’Donnell talked about her ‘shocking’ new size after taking the medication. 

In a TikTok video uploaded at the time, she explained to her followers: ‘I am on Mounjaro for my diabetes and one of the side effects is you lose weight.

Social media users jumped to the comment section to share their thoughts on Rosie’s weight loss

Another asked the star how many pounds she has dropped since taking Mounjaro and typed, ‘Fabulous!! How much weight in total? I’m on the same journey,’ with O’Donnell replying with, ‘Dunno’

Back in March of this year, O’Donnell talked about her ‘shocking’ new size after taking the medication; seen in 2024 in L.A. 

‘But [the weight loss] is also because I had a chef for over two years in Los Angeles and I don’t have a chef now. It’s me cooking for [my child] Clay and me.’

The TV personality then recalled how she went to a clothing store in Dublin and revealed she was a size large after previously wearing sizes XL or XXL. 

‘I find it shocking. I really do. I find it completely shocking,’ the mom-of-five expressed. 

Being on Mounjaro has not only aided her in losing weight, but has made her feel ‘healthier’ and she is also ‘sleeping better.’ 

Back in January 2023, O’Donnell explained that she had dropped 10lbs after being on the drug over the holiday season when she was prescribed the medication by her doctor. 

While taking her child to school, the star explained on TikTok: ‘I need to let you know I’ve lost 10lbs since Christmas.’

She added that she has been taking Mounjaro after a fan commented, ”You can’t drop a bomb like that and not tell us HOW???’

Rosie stated, ‘Okay, so like two months ago, my doctor put me on… not Ozempic, Mounjaro? Something like that, and Repath.’ 

Rosie stated, ‘Okay, so like two months ago, my doctor put me on… not Ozempic, Mounjaro? Something like that, and Repath’

She added, ‘One I do every other week, and one I do once a week. And that and on Christmas, I stopped drinking anything except water. 

‘Now I have had champagne one night, that was a toast, and some wine one night, so it hasn’t been 100% but I really stopped drinking like five or six Diet Coke’s a day.’ 

Rosie now only sticks to drinking water and has reduced her sugar intake while also sharing, ‘And my appetite has decreased significantly.

‘It’s probably the meds, and I’m trying to move more, so all of those things combined, that’s what it is.’ 

Another fan mentioned the high cost of Mounjaro and the actress stated, ‘Yeah you have to have diabetes to get a prescription. That’s what I heard. 

‘People are doing Ozempic parties here in L.A. where they all do Ozempic, but I have diabetes too, so that’s why I’m on it.’ 

O’Donnell suffered a previous health scare when she had a heart attack at the age of 50. 

She previously reflected on the health incident during an appearance on The Best Podcast Ever in 2023 and admitted that she ‘should’ve died.’

‘People are doing Ozempic parties here in L.A. where they all do Ozempic, but I have diabetes too, so that’s why I’m on it,’ she said; seen in 2020 

She previously reflected on the health incident during an appearance on The Best Podcast Ever in 2023 and admitted that she ‘should’ve died’; seen in 2013 in NYC 

While in the parking lot of a hospital to pick up a friend, the star ended up helping a stranger nearby. 

‘She said ‘Rosie, will you help me up?’ So I went over and I helped her up and it took a lot longer than I expected.

‘I got home and my arms were hurting. I thought, ‘That’s funny, it must’ve been from pushing her up.’ So I went about my business.’ 

The media personality looked up her symptoms but opted to not immediately see a doctor at the time. She then recalled having a heart attack on a Monday but didn’t go to the hospital until two days later. 

Upon seeing a cardiologist, Rosie was told she was having a ‘massive heart attack’ and was rushed to the emergency room. 

‘I was like, ‘Wait, wait, what?!’ I couldn’t believe it. And then I came to find out that the symptoms for a woman having a heart attack are very different than the symptoms for men having heart attacks.’

Rosie and her nonbinary child Clay relocated to the country after Trump’s U.S. presidential win in November 2024

The former talk show host added, ‘Yet what we see on TV are always men having heart attacks.’

Along with keeping her fans updated amid her health journey, the star has also been documenting her new life in Ireland. 

Rosie and her nonbinary child Clay relocated to the country after Trump’s U.S. presidential win in November 2024. 

She has also returned to doing stand-up and has a few upcoming shows on select dates between May 28-July 23 at the International Bar in Dublin.