A high-profile murder trial is set to begin Monday in Colorado, where prosecutors allege that a local dentist murdered his wife by poisoning her protein shakes with cyanide – all while secretly carrying on an affair and plotting a new life without her.

James Toliver Craig, 47, is charged with first-degree murder after deliberation in the March 2023 death of his wife, Angela Craig, a 43-year-old mother of six. 

The high-stakes trial is expected to last approximately three weeks.

James’ trial was delayed in November 2024 when attorney Harvey Steinberg withdrew from the case, just weeks before the trial was set to begin.

Steinberg told the court that James Craig was insisting on pursuing a legal strategy that Steinberg believed was unethical, possibly illegal or fraudulent.

Due to this last-minute withdrawal, the court granted continuance to allow James to hire new legal counsel and allow the new attorneys time to review the case.

The trial was rescheduled and officially begins with jury selection on Monday, July 14. Proceedings are expected to run through Aug. 1.

Fox News Digital’s Mollie Worthy contributed to this report.