Vitamin D is well-known for its positive effects on bone health, muscle strength, and immune function. In addition to these benefits, it also shows promise in cancer prevention.

A new study published in the journal Nutrients suggests that the common vitamin is effective in preventing and treating colorectal cancer.

A group of Hungarian researchers conducted a thorough analysis of 50 previous studies involving over 1.3 million participants. The focus was on the potential impact of vitamin D on cancer risk, immunity, and inflammation.

According to János Tamás Varga, PhD, an associate professor at Semmelweis University in Budapest and the lead author of the study, a key finding was the critical role of vitamin D in both preventing and treating colorectal cancer.

“Our research clearly supports the strong correlation between 25-hydroxyvitamin D (the primary form of vitamin D) levels and cancer outcomes.”

Cancer patients with low vitamin D levels showed poorer prognoses.

Vitamin D has been shown to reduce inflammation, promote the death of cancer cells, inhibit tumor growth and enhance immune response, the researchers found. 

“These mechanisms significantly influence the pathophysiology of colorectal cancer,” Varga noted. 

In addition to prevention, vitamin D supplementation was also shown to improve survival rates among patients with advanced-stage colorectal cancer, according to the research.

“The results suggest that the effect of vitamin D may depend on factors such as the dosage, the individual condition of the patients and the duration of treatment,” Vargas added.

The American Cancer Society (ACS) has previously referenced studies suggesting that vitamin D could lower cancer risk, particularly colorectal cancer.

“However, large studies have not found that vitamin D supplements lower the risk of colorectal polyps (pre-cancerous growths) or cancer,” the ACS stated on its website.

One important limitation of the research is that the studies included in the analysis used different vitamin D dosages and involved patients at various stages of cancer, the authors noted. 

They called for further research to accurately determine the optimal dosage and “therapeutic efficacy.”

Recommendations for Americans

“Based on our research, we recommend that individuals at high risk of colorectal cancer monitor their vitamin D levels and, if necessary, take a daily vitamin D supplement of 1000–4000 IU, especially for those with low vitamin D levels,” lead study author Dr. Monika Fekete, medical doctor at Semmelweis University, told Fox News Digital.

“The optimal dosage should be tailored to the individual’s health condition and current vitamin D levels.”

For physicians, the researchers suggest routinely measuring and supplementing vitamin D levels for both prevention and treatment purposes.

“Vitamin D plays a crucial role in the treatment and prevention of colorectal cancer, but further research is needed to determine the optimal dosage and the specific role of genetic factors,” Fekete added.

“The molecular mechanisms of vitamin D — such as the regulation of oncogenes (mutated genes that can lead to cancer) and inhibition of tumor progression — require further scientific investigation.”

As the effect of vitamin D is closely linked to the patient’s condition, the doctor said, treatment recommendations should be personalized.

The primary source of vitamin D is exposure to the sun’s ultraviolet (UV) rays.

It can also be obtained from dietary sources, according to the ACS, including fatty fish and some mushrooms.

There are also some vitamin D-fortified foods, including milk, some orange juices and cereals, the above source stated.

People can also take vitamin D supplements to boost their levels.

“Most Americans do not get enough vitamin D in their diets, and many have low vitamin D levels in their blood,” the ACS said on its website. 

“While the role of vitamin D in lowering cancer risk is still an active area of research and debate, avoiding low vitamin D levels is recommended.”