On Saturday, President Donald Trump issued a stern warning of “very serious retaliation” following an ambush by an Islamic State gunman in Syria that resulted in the deaths of two U.S. Army soldiers and a U.S. interpreter.

Sean Parnell, the Chief Pentagon spokesperson, revealed that the attack took place in the central Syrian town of Palmyra. The incident, which targeted American personnel, also left three others injured. According to U.S. Central Command, the tragic event was the result of an ambush by a single ISIS gunman.

Trump expressed his condolences on Truth Social, stating, “We mourn the loss of three Great American Patriots in Syria, two soldiers, and one Civilian Interpreter. We also pray for the three injured soldiers, who, we have just been informed, are recovering well. This was an ISIS attack against both the U.S. and Syria, in a very dangerous region not fully under control.”

He continued by mentioning that “Ahmed al-Sharaa, the President of Syria, is deeply angered and disturbed by this assault. There will be very serious retaliation.”

U.S. forces are seen patrolling in the northeastern city of Qamishli, located in Syria’s Hasakeh province, on January 9, 2025. (Photo by Delil Souleiman/AFP via Getty Images)

In comments to reporters outside of the White House on Saturday, Trump also said, “This was an ISIS attack on us and Syria. And again, we mourn the loss and we pray for them and their parents and their loved ones.”

Parnell wrote on X that the attack happened as the soldiers “were conducting a key leader engagement.”

“Their mission was in support of ongoing counter-ISIS/counter-terrorism operations in the region,” he added, noting that “The soldiers’ names, as well as identifying information about their units, are being withheld until 24 hours after the next of kin notification. “

Secretary of War Pete Hegseth said that, “The savage who perpetrated this attack was killed by partner forces.”

“Let it be known, if you target Americans — anywhere in the world — you will spend the rest of your brief, anxious life knowing the United States will hunt you, find you, and ruthlessly kill you,” Hegseth also said in a post on X.

Parnell said the attack is currently under investigation. A Pentagon official told Fox News Digital that the attack unfolded in a place where the Syrian President Ahmed al-Sharaa does not have control.

President Donald Trump meets with Syrian President Ahmed al-Sharaa at the White House on Nov. 10, 2025. A Pentagon official told Fox News Digital that the attack on the soldiers on Saturday, Dec. 13, 2025, unfolded in a place where the Syrian President Ahmed al-Sharaa does not have control. (Syrian Presidency/Anadolu via Getty Images)

“I’m praying for the brave U.S. soldiers and civilian who lost their lives, those who were injured in this attack, and the families who bear this profound loss,” Army Secretary Daniel Driscoll wrote on X. “The men and women who serve our country represent the very best of our nation. We mourn the passing of these heroes and honor their service and sacrifice.”

A senior U.S. official earlier confirmed to Fox News there were multiple injuries after American service members were ambushed in Syria.

“The United States, CIA and military forces are reportedly deeply involved in securing and stabilizing the situation in Syria,” Dan Diker, president of the Jerusalem Center for Security and Foreign Affairs, recently told Fox News Digital.

The injured in Saturday’s attack were taken by helicopters to the al-Tanf garrison, which is near the border with Iraq and Jordan, The Associated Press reported, citing Syrian state media.

U.S. Army soldiers prepare to go out on patrol from a remote combat outpost on May 25, 2021, in northeastern Syria.  (John Moore/Getty Images)

There are currently around 900 U.S. troops in Syria.

The U.S. had eight bases in Syria to keep an eye on ISIS since the U.S. military went in to prevent the terrorist group from setting up a caliphate in 2014, although three of those bases have since been closed down or turned over to the Syrian Democratic Forces.

On Monday, tens of thousands of Syrians flooded the streets of Damascus to mark the first anniversary of the Assad regime’s collapse.

U.S. Army soldiers stand near an armored military vehicle on the outskirts of Rumaylan in Syria’s northeastern Hasakeh province, bordering Turkey, on March 27, 2023.  (Delil Souleiman/AFP via Getty Images)

Those celebrations came a year after former Syrian dictator Bashar al-Assad fled the capital as rebel forces swept through the country in a lightning offensive that ended five decades of Assad family rule and opened a new chapter in Syrian history.