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The Pima County Sheriff, Chris Nanos, announced that DNA evidence collected from both a glove found near Nancy Guthrie’s residence and from inside her home has failed to yield any matches in the FBI’s database.
In a conversation with Fox News, Sheriff Nanos explained that the DNA samples from the crime scene did not correspond with any profiles in the FBI’s Combined DNA Index System (CODIS). Additionally, the DNA discovered on the glove was distinct from the samples obtained within Guthrie’s home.
Guthrie was reported to have been forcibly abducted from her Tucson, Arizona home during the early hours of February 1, with authorities asserting that she did not leave voluntarily. The sheriff expressed a measure of optimism about the ongoing investigation, even though the recent DNA analysis did not lead to a breakthrough.
“We remain hopeful that progress is being made,” Nanos stated. “Unfortunately, the latest update this morning confirmed that the DNA on the glove found two miles away showed no matches in CODIS.”
As the investigation into Guthrie’s disappearance continues, FBI agents have been actively canvassing the neighborhood surrounding her Tucson home. The last confirmed sighting of Nancy Guthrie was on a Saturday night prior to her disappearance, intensifying concerns for her safety. A poignant photograph of Nancy Guthrie with Savannah Guthrie, provided by NBC, has been circulated to assist in the search efforts. (Photo credits: Kat Ramirez for Fox News Digital; Courtesy of NBC)
While DNA found inside Guthrie’s home and on a glove near her residence didn’t produce a hit in the FBI’s database, the Pima County Sheriff’s Office said in an X post that DNA found at her property is still being analyzed.
“The DNA that was submitted to CODIS was from the set of gloves found 2 miles away. It did not trigger a match in CODIS and did not match DNA found at the property. The DNA found at the property is being analyzed & further testing needs to be done as part of the investigation,” the sheriff’s office wrote.
DNA Labs International, where the sample was sent, is closed on weekends, a spokesperson told Fox News Digital. The spokesperson added that the office was closed on Feb. 14 and 15, adding the lab is “able to be open on the weekend if it’s requested.”
Savannah Guthrie and her mother Nancy Guthrie are pictured Thursday, June 15, 2023. (Nathan Congleton/NBC via Getty Images)
Retired FBI special agent Jason Pack told Fox News Digital that investigators will likely turn to “Investigative genetic genealogy” since there wasn’t a match for the DNA in the FBI’s CODIS database.
“[Investigators] go here: Investigative genetic genealogy, or IGG, is a technique the FBI uses that combines DNA analysis from crime scenes with searching publicly available commercial genealogy databases and old-fashioned genealogy research,” Pack said. “It is completely different from CODIS, the FBI’s law enforcement DNA database that only compares crime scene DNA against people who have already been arrested or convicted.”
A growing vigil in the morning light under cloudy skies is seen at Nancy Guthrie’s home on February 13, 2026, in Tucson, Arizona. (Ty ONeil/AP Photo)
The technique was used to catch the Golden State Killer in 2018, who killed at least 13 people and sexually assaulted another 50 women after investigators uploaded DNA found at the crime scene to a genecology database and found a distant cousin. The distant cousin was used to build a family tree which eventually led investigators to Joseph DeAngelo.
Photos released on Feb. 10, 2025, show a “subject” on Nancy Guthrie’s property. (Provided by FBI)
In an emotional video released Sunday, NBC “Today” show host Savannah Guthrie said, “it is never too late to do the right thing”.
“I just wanted to come on and say that we still have hope and we still believe. And I wanted to say to whoever has her or knows where she is. It’s never too late. And you’re not lost or alone,” Guthrie said. “We believe in the essential goodness of every human being. And it’s never too late.”
Nancy Guthrie disappearance timeline:Â
Jan. 31, 2026
• Between 9:30–9:45 p.m. – Family drops Nancy off at home
• 9:50 p.m. – Garage door closes (per authorities)
Feb. 1, 2026
• 1:47 a.m. – Doorbell camera disconnects
• 2:12 a.m. – Security camera detects motion
• 2:28 a.m. – Pacemaker disconnects from phone application
• 11:56 a.m. – Family checks on Nancy after she misses weekly church livestream gathering
• 12:03 p.m. — 911 called
• 12:15 p.m. — Sheriff’s deputies arrive at home