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Potential Anti-Aging Drug Extends Animals’ Lifespan by 25% in Study

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Scientists in the UK have moved a step closer to understanding how ageing might be slowed after creating a drug that extended the lives of several animals.

The experimental compound, known as 991, increased the lifespan of yeast, worms and flies by as much as 25 per cent.

The drug activates AMPK, a protein that helps cells preserve and generate energy during periods of stress, exercise or fasting. Researchers have long believed that this natural survival response could also delay some of the biological processes linked to ageing.

The findings raise the possibility that the same approach could eventually benefit humans, although scientists stress that much more research is needed.

Professor Filipe Cabreiro, of the UK’s Medical Research Council (MRC), said: ‘The field is still a long way from anti-ageing clinical trials in humans. This is because ageing is not technically classified as a disease.

‘But improving health in older age would be hugely beneficial from a societal and healthcare perspective, since ageing is a major risk factor for so many diseases, such as heart disease, diabetes, cancer and dementia.

‘The ability to make individuals healthier for longer, for instance by pharmacologically targeting energy balance through AMPK, would be a major biomedical breakthrough.’

The experimental drug extended the lifespan of yeast, worms and flies by up to 25 per cent, the study showed

The study found that the experimental drug extended the lifespan of yeast, worms and flies by up to 25 per cent

AMPK is often called the body’s ‘fuel gauge’ because it continuously monitors the amount of energy available inside cells.

When energy supplies decline, AMPK functions as a biological switch. It suppresses processes that consume large amounts of energy while activating systems that produce more fuel.

Exercise, fasting and other forms of physical stress naturally stimulate the enzyme, allowing cells to adapt when resources are scarce.

Interest in AMPK has grown because the protein affects several processes associated with ageing, including metabolism, inflammation and cellular repair.

As a central part of the body’s metabolic network, AMPK has also been connected with conditions such as obesity, type 2 diabetes, cardiovascular disease and dementia.

Some widely used medicines, including the diabetes drug metformin, are known to activate AMPK. This has prompted researchers to investigate whether the pathway could be used to support healthier ageing.

However, many of these medicines activate AMPK indirectly, which makes their biological effects more difficult to establish and interpret in both laboratory studies and clinical research.

The drug, called 991, works by triggering a protein called AMPK that governs energy levels in the body

The experimental drug 991 activates AMPK, a protein that regulates energy levels inside the body

To address this limitation, the researchers used 991 to activate AMPK directly in fission yeast, nematode worms and fruit flies.

These organisms were selected because their relatively short lifespans allow scientists to study the effects of potential anti-ageing treatments more quickly.

Dr Helena Cochemé, who leads the Redox Metabolism Group at the MRC, said: ‘The fact that we can extend lifespan in yeast, worms and flies is very exciting.

‘Worms and flies in the lab live for around three weeks and three months respectively, …so we can make progress and discoveries much more rapidly and efficiently than in mammalian systems.

‘Our study is the first demonstration that directly targeting AMPK using a drug can have longevity benefits in living organisms.

‘If a treatment works successfully in three such distantly related species, then these results give us more confidence that in the longer-term, the effects possibly translate to mammals and eventually perhaps humans.’

Having demonstrated clear longevity benefits in yeast, worms and flies, the scientists are now aiming to see whether the same effects can be replicated in mice.

They say the fact that direct AMPK activators have already shown a good safety profile in trials for metabolic conditions raises hopes that the drugs could one day be used more widely in medicine.

The study, published in the journal Aging Cell, was primarily publicly funded by the MRC, part of UKRI.

The research also involved contributions from scientists at Queen Mary University of London, the Francis Crick Institute and the University of Lyon. 

Indiana Mom Allegedly Killed in DUI Hit-and-Run by Biden-Era Migrant

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An Indiana mother was allegedly killed in a drunk-driving hit-and-run involving a Honduran national who entered the United States unlawfully during the Biden administration, according to the Department of Homeland Security.

Tamara Thomas, 33, was waiting in the parking lot of an Indianapolis gas station Saturday when she was struck by a vehicle allegedly driven by Edwin Alexander Sosa-Gonzalez, DHS said.

According to police records reviewed by the Indianapolis Star, the 22-year-old was speeding in a gray Honda CR-V when he hit another vehicle. The collision sent his SUV over the curbs.

Thomas, who had been waiting for her two brothers to pick her up, tried to move out of the way. She was struck by the Honda and pronounced dead at the scene.

Sosa-Gonzalez allegedly drove away but was arrested several hours later. Investigators said he smelled of alcohol, was stumbling and had slurred speech, according to court documents.

Authorities said his blood alcohol concentration measured 0.229, nearly three times Indiana’s legal limit. He was charged with operating a vehicle while intoxicated.

DHS said Sosa-Gonzalez also faces charges for leaving the scene of an accident involving death or catastrophic injury, as well as leaving the scene of an accident resulting in death.

Sosa-Gonzalez entered the United States illegally through Texas in July 2021, DHS said. He was arrested by U.S. Border Patrol and later released during the Biden administration.

He was subsequently placed in Immigration and Customs Enforcement custody after a February 2024 arrest involving allegations that he drove while intoxicated and without ever obtaining a driver’s license.

ICE filed a detainer Sunday, one day after the fatal crash. DHS Secretary Markwayne Mullin also criticized the Biden administration’s immigration policies.

“This illegal alien, who had been released into our country by the Biden Administration, took the life of 33-year-old Tamara Renee Thomas because he was drunk behind the wheel,” Mullin said.

“He has now been charged with hit-and-run and driving under the influence.

“ICE has lodged a detainer asking officials in Indiana to cooperate with us and make sure this killer never gets back onto the streets again.

“This disaster was completely avoidable, and were it not for the reckless open-border policies of the Biden Administration, this woman would still be alive. My thoughts and prayers are with Tamara’s family and friends.”

Tamara’s father, Tommy Thomas, said he intends to provide his daughter with the best funeral possible. He also spoke about his regret over the role he believes he may have played in her difficult life, noting that he previously served prison time for dealing LSD.

“It should’ve never happened,” he told Fox59.

“My daughter’s had a crap life,” he said. “I might have had some part in that at one point in time.

“I wanna give her the best burial, I wanna give her the most proper burial that I can.”

He said he hopes to scatter Tamara’s ashes in Hawaii if the family chooses cremation.

Tommy Thomas was candid about how his daughter, who dropped out of school before she reached the seventh grade, had struggled with drugs – but said she had “recently started getting clean.”

He lamented how Thomas, who was a mom to a son, was killed by an allegedly drunk driver rather than substances.

“It wasn’t even the drugs or the normal sideshow of people that she hangs out with on a daily basis,” he said.

Tommy Thomas also said he wished his daughter had died from drugs.

“There was a long time that I really thought I was going to get a call that she was gone, and it was going to be because of a drug overdose,” he told WTHR.

“And I hate to say it, but I wish it had been an overdose. I hate to know how much pain, if any, that she went through, you know, pinned underneath that car, and when that guy hit her.”

Diddy Receives Earliest Release Date Yet in Federal Prison Sentence Update

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Sean “Diddy” Combs is now expected to leave federal prison sooner than previously projected.

The music executive was initially due to remain behind bars until May 8, 2028. However, his projected release date has since been brought forward.

Records from the Federal Bureau of Prisons list Combs, whose legal name is Sean Combs, as scheduled for release on January 21, 2028.

Juda Engelmayer, a spokesperson for Combs, told The Daily Mail: “We never know how or why the BOP calculates and posts these dates.”

Combs was sentenced last year to four years and two months in prison after being convicted on two prostitution-related charges following his highly publicized federal trial.

His projected release date has shifted several times since he began serving the 50-month sentence. Most recently, it had been listed as February 5.

Diddy's release date has been moved to January 21, 2028 - four months earlier than his original release date; pictured 2023

Diddy’s projected release date is now January 21, 2028—four months earlier than the original estimate; pictured in 2023

At trial, a jury convicted Combs on two counts of transporting prostitutes across state lines for prostitution. He was cleared of the more serious allegations of racketeering and sex trafficking.

His former girlfriend Cassie Ventura also gave graphic testimony during the proceedings, alleging that Combs had abused her over a period of more than 10 years.

Combs had originally been expected to complete his sentence and leave prison in May 2028, but the date was revised repeatedly.

The projected date was first moved back to June 4, 2028 after allegations emerged that Combs had consumed moonshine and placed an unauthorized three-way phone call. His attorney denied the claims.

In October, Combs received a reduction that moved the date to April 25, 2028. The change was attributed to the FIRST STEP Act, a prison reform law enacted during Donald Trump’s first presidency and publicly supported by Kim Kardashian. The legislation has contributed to the early release of tens of thousands of federal inmates.

Further updates followed, eventually bringing the projected release date to January 21—the earliest date at which Combs is currently expected to be freed.

Combs has also reportedly faced disciplinary issues while incarcerated.

Alongside the disputed moonshine claim, TMZ reported that he was involved in an altercation with another inmate earlier this year.

A jury found Diddy guilty of two counts of transporting prostitutes across state lines for the purpose of sex at his federal trial. He was acquitted by the jury on the more serious charges of racketeering and sex trafficking; a courtroom sketch of Diddy during his sentencing hearing

A jury convicted Diddy on two counts of transporting prostitutes across state lines for prostitution, while acquitting him of racketeering and sex trafficking; pictured in a courtroom sketch during his sentencing hearing

Sean Combs' release date has moved a number of times since he started serving his 50-month sentence; pictured 2022

Sean Combs’ release date has been revised multiple times since he began serving his 50-month sentence; pictured in 2022

Responding to the moonshine allegations, a statement posted to the Bad Boy Entertainment founder’s X account said: “The rumors claiming Mr. Combs was caught with alcohol are completely false.”

“His only focus is becoming the best version of himself and returning to his family.”

A representative for the “I’ll Be Missing You” artist likewise told the Daily Mail that Combs “has not violated any prison rules” and is concentrating on maintaining his sobriety while completing his sentence.

‘His sobriety and self-discipline are priorities,’ the spokesperson said, ‘and he is taking them seriously.’

Combs’s representative also noted that ‘this is only his first week at FCI Fort Dix, and unfortunately, rumors will surface throughout his time there.’

‘We ask the public and the press to give him the benefit of the doubt, the privacy to focus on his personal growth, and the grace to move forward in peace.’

During Combs's trial, his ex-girlfriend Cassie Ventura delivered graphic testimony; pictured 2017

During Combs’s trial, his ex-girlfriend Cassie Ventura delivered graphic testimony; pictured 2017

While on the stand, Cassie alleged the music mogul abused her over more than a decade; a courtroom sketch of Cassie

While on the stand, Cassie alleged the music mogul abused her over more than a decade; a courtroom sketch of Cassie 

Just a few days later, however, Combs reportedly got into trouble for making a three-way call in violation of prison rules.

But Combs said he was simply speaking with his lawyer, who added that the head of legal communications was working on a statement for his approval to be sent to The New York Times.

Following his time in prison, the judge sentenced Combs to another five years of supervised release.

Judge Arun Subramanian said a lengthy sentence was needed for deterrence and that he was unconvinced that if Combs is released, these crimes won’t happen again.

The judge condemned Combs for his ‘savage’ abuse of Ventura and said he was making an example of him because he caused ‘irreparable harm’ to his victims.

TSA Officers Can’t Sit While Checking IDs and Boarding Passes

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WASHINGTON, D.C. — Transportation Security Administration employees who verify travelers’ IDs and boarding passes will no longer be permitted to sit on the job, the agency confirmed Tuesday.

Chairs are being taken away from document-checking podiums at security checkpoint entrances across the country, according to the union representing TSA officers. The American Federation of Government Employees TSA Council 100 said workers alerted it to the policy and criticized the decision as a “disregard for workers rights and safety.”

TSA said the change is intended to improve the passenger experience. Because document-checking officers are typically the first agency employees travelers encounter, the agency said having them stand will help create a more attentive and welcoming checkpoint environment.

“This welcome change reinforces both our security posture and our commitment to hospitality by having these officers on their feet and alert,” the agency said in a statement. “All officers must meet fitness for duty requirements to be capable of performing their vital national security function while simultaneously creating a welcoming and professional environment for travelers.”

The policy shift follows the confirmation of TSA Administrator David Cummins, who took charge of the agency nearly two months ago.

According to the union, chairs have already been removed from most major commercial airports. One union leader said AFGE and its local chapters did not receive formal notice before the removals began.

“These chairs serve as basic ergonomic and safety support for officers that stand and walk on hard surfaces all day,” AFGE Council 100 said in a statement. “TSA is treating this matter like it is a privilege – it is not; it is basic safety and common decency for the workforce.”

The change arrives as TSA prepares to mark the 25th anniversary of its creation in November. Cummins has been meeting with officials to “rapidly advance key strategic initiatives” under an agency effort known as Horizon 25.

“TSA does not have to choose between a secure checkpoint, an efficient checkpoint, and an elevated passenger experience,” Cummins said in a statement introducing the initiative.

Horizon 25 calls for broader TSA PreCheck access, the introduction of new technology, the privatization of certain checkpoints and efforts to improve the travel experience. The agency has not said whether requiring document-checking officers to remain standing is part of that broader transformation.

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Connecticut Man Ahmad Elshazly Sentenced for Attempting to Support ISIS

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Ahmad Khalil Elshazly, 29, of West Haven, Connecticut, has been sentenced to 92 months in federal prison—more than seven and a half years—for attempting to provide support to ISIS, the Islamic State group designated as a terrorist organization by the United States, the US Department of Justice said Monday.

“There is no higher priority than the security of our nation and its citizens,” US Attorney for the District of Connecticut David X. Sullivan said. “My office and our law enforcement partners will continue to tenaciously work to investigate, apprehend and bring to justice anyone who threatens us.”

Elshazly has been held in custody since his arrest on Dec. 15, 2019. After completing his prison sentence, he will remain on supervised release for the rest of his life, according to the Justice Department.

Ahmad Khalil Elshazly of West Haven, Conn., was sentenced to 92 months in prison for trying to support the Islamic State before his arrest in 2019. Office of the Chairman of the Joint Chiefs of Staff

The day before his arrest, Elshazly gave $500 to an undercover agent he believed was working with ISIS.

He believed the individual would help smuggle him from the United States to Turkey, where he expected to be connected with an ISIS member who could assist him in reaching Syria.

Federal officers arrested Elshazly in Stonington, Connecticut, before he could board a boat, the Justice Department said.

Court documents state that during the 15 months leading up to his arrest, Elshazly pledged allegiance to ISIS and published “hundreds” of messages supporting the group on an instant-messaging platform.

He pleaded guilty on Nov. 30, 2022, to conspiring to provide material support to a terrorist organization.

The Justice Department also said Elshazly committed numerous disciplinary violations while detained. In August 2025, officers searching his cell reportedly discovered a handwritten plan for a coordinated uprising at the detention facility. The document included diagrams of the housing unit, directions for breaching secured areas and tactics for confronting the correctional emergency response team.

In the 15 months prior to his arrest, Elshazly swore allegiance to ISIS and posted “hundreds” of pro-ISIS messages on an instant-messaging platform, per court documents.

In the 15 months prior to his arrest, Elshazly swore allegiance to ISIS and posted “hundreds” of pro-ISIS messages on an instant-messaging platform. REUTERS

Prosecutors had sought a 15-year sentence. Elshazly’s attorneys, however, argued that “treating Mr. Elshazly with compassion will show those who practice the Muslim faith that the United States is not the enemy of Islam that the radical Islamists claim the US to be.”

In a sentencing memorandum filed Sept. 1, his lawyers described Elshazly as having endured “a chaotic upbringing, an unequipped mother, educational failure, low self-esteem, extreme isolation, the stupidity of youth, never treated Autism Spectrum Disorder and bouts of depression.” They said those circumstances “made him vulnerable to the toxic Syrian and ISIS propaganda he found while unsupervised and alone in his bedroom.”

“A disappointment to himself and others in real life, he became increasingly mired in fantasy, making cinematic promises of bold military actions and boasting of skills and abilities, such as rocket manufacturing, that were entirely nonexistent,” his attorneys wrote. They said his autism and related challenges “could be successfully addressed in therapy.”

Ohio Cancer Patient Sues Hospital Over Alleged Wrong-Leg Amputation

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An Ohio woman has filed a lawsuit alleging that surgeons amputated the wrong leg during a below-the-knee procedure intended to treat cancer in her right leg.

Sharon Jacks, who is now a double amputee, was scheduled for surgery on her right leg at Selby General Hospital in Marietta on Sept. 19, 2025. Instead, she awoke to find that her left leg had been removed, according to the lawsuit reported by WBNS.

“She went into surgery, and when she woke up, the wrong leg had been taken off,” Jacks’ attorney, Brad Layne, told the outlet. “It defies explanation, obviously.”

The right leg, which was the intended site of the operation, was later amputated as well, leaving Jacks without either leg.

Selby General Hospital

Sharon Jacks was scheduled for a below-the-knee amputation of her right leg at Selby General Hospital, but she awoke to discover that her left leg had been removed. (Google Maps)

The lawsuit names Selby General Hospital, the surgeon and other members of the operating team. It accuses them of “a complete failure of basic safety procedures.”

In a press release, Layne said “there is simply no excuse” for the error, describing it as a “complete and total failure by multiple medical professionals” that caused what he called a catastrophe.

“Despite several opportunities to identify the mistake and stop the procedure, the surgical team somehow never noticed they were operating on the wrong leg,” Layne said. “Now every day for the rest of her life, Sharon Jacks must live with the consequences of those failures.”

Layne said the medical records he reviewed show that the surgeon initially marked the correct leg, yet the team still amputated the other one.

“The mark was still on the correct leg after the wrong leg had been taken off,” Layne said.

The complaint says the team conducted two surgical “time-outs” before the operation. Such checks are intended to confirm the patient’s identity, the planned procedure and the correct surgical site before an incision is made.

The lawsuit names the hospital, the surgeon and other members of the surgical team, alleging “a complete failure of basic safety procedures.” (iStock)

“Every person in that operating room is responsible to make sure that that is verified before moving forward, and that includes the doctor, the staff, the nurses, the anesthesiologist, everybody that’s involved,” Layne said.

“The records say that happened twice, but somehow Ms. Jacks is missing a leg that should have not been removed,” he added.

The lawsuit describes wrong-site surgery as one of the most serious preventable medical errors. In healthcare, such incidents are commonly classified as “never events” because they are not expected to occur.

“It shouldn’t happen in any type of medicine. It shouldn’t happen anywhere. It shouldn’t happen in a veterinary setting, even,” Layne said.

Jacks is seeking compensatory and punitive damages for past and future medical costs, pain and suffering, emotional distress, permanent impairment and the loss of enjoyment of life.

Medical staff perform a procedure in an operating room with surgical instruments visible in the foreground.

The lawsuit seeks compensatory and punitive damages for Sharon Jacks, including compensation for past and future medical expenses, pain and suffering, emotional distress, permanent impairment and loss of enjoyment of life. (Getty Images)

Selby General Hospital confirmed that an “adverse surgical event” occurred in September 2025. The hospital said the surgical team “responded immediately to address the medical needs of the patient involved and provide support to their family.”

In a statement to WBNS, the hospital said its review determined that the incident was avoidable and that required operating-room procedures had not been followed. The hospital added that those involved were held accountable and are no longer employed in their positions.

The hospital said it has fully cooperated with a review by the Ohio Department of Health, saying the review confirmed its surgical protocols are “safe and effective” and that its clinical and leadership teams “have implemented corrective measures across our organization to prevent a situation like this from recurring.

“We are saddened by what occurred, and our team continues to keep this patient and their family in our prayers,” the statement reads.

Sarah Vine: Why Does Labour Hate What Makes Britain Special?

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Pauline Hanson Claims Australian PM Anthony Albanese Is Plotting a “Big Problem”

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Pauline Hanson believes Anthony Albanese could call an election late next year as part of a political strategy that would leave any incoming conservative government facing a difficult Senate landscape. Labor and the Greens would be likely to retain effective control of the upper house for months after the vote.

In an exclusive YouTube interview with Daily Mail’s Politics and Economics Editor Peter van Onselen in Wagga Wagga last week, the One Nation leader said she suspected the Prime Minister was preparing a political ambush.

Hanson said she expects Albanese to seek an early election in late 2027. Under that scenario, Labor and the Greens could continue to wield effective Senate control until July 2028, regardless of the election result, because newly elected senators do not begin their terms immediately.

Following a half-Senate election, newly elected senators take office on July 1.

“If he has an election at the end of next year, Labor will still control the Senate till July 2028,” Hanson said.

“That could be a big problem for whoever is (in) government.”

The timing could create major obstacles for a government not led by Labor, including one that depended on One Nation to hold the balance of power—even if the Coalition or another alternative secured a decisive victory at the ballot box.

“We have to work together to get rid of the toxic Labor-Greens government,” she said.

Pauline Hanson (pictured) said she thought Albanese was plotting to hold an early election

Pauline Hanson (pictured) said she believed Anthony Albanese was preparing to call an early election

“It’s very important that we do that, and I’m not going to be half-hearted about this.”

Hanson also attributed One Nation’s growing support over the past two years to voters reassessing warnings she says she has delivered for decades about immigration, social cohesion and government policy.

“People are going back looking at my speeches, what I’ve said,” she said.

“People are always saying, ‘She’s been warning us about this for so long.’ Now they’re finally—the light switch is going on.”

The One Nation leader has recently pointed to cultural and national security concerns as key reasons some voters are moving towards her party.

But in one of her most direct explanations yet, she singled out two events that she believes helped accelerate that political shift.

“The big turning point was also the Charlie Kirk assassination and also the other one was the Bondi massacre,” Hanson said.

Hanson said the December 14 terror attack at Bondi Beach, which claimed 15 lives, intensified concerns she had been raising for years.

Hanson said the Bondi Beach terror attack was a 'turning point' leading to a rise in her support

Hanson described the Bondi Beach terror attack as a “turning point” that contributed to rising support for One Nation

“These are things that I’ve spoken about,” she said.

‘I was ridiculed for it, speaking about radical Islam, and I’ve been warning people out there about it.’

‘People are now seeing what’s happening in other countries around the world, they see it happening in Australia and they know that I’m the only one who’s prepared to call it out.’

Hanson also pointed to a growing distrust of mainstream politicians as a major factor behind One Nation’s rise.

‘People don’t trust politicians, but people know that I’m so patriotic to this country that I say what I mean, I mean what I say, and I’m not two-faced,’ she said.

‘A lot of politicians are.’

Hanson said she believed that One Nation could win the next election. 

‘We are in the mix with this and it’s where we’re getting the support from the Australian people,’ she said.

Barnaby Joyce (pictured) said there was an ‘Aunty Pauline effect’ driving the One Nation surge

‘I expect to be treated with a little bit more respect and taken seriously.’

Joyce, who has become one of One Nation’s most valuable assets, said voters were increasingly drawn to Hanson because they viewed her as authentic. 

‘At the start people thought Pauline was abrupt,’ Joyce said.

‘Then there was more of what I call the “Aunty Pauline effect”, where people say she’s straight down the barrel, no doubt about that, but it comes from a good place.’

‘People might not agree with everything she says, but they know exactly where she stands.’ 

The former deputy prime minister said Australians were looking for alternatives as cost-of-living pressures mounted and confidence in traditional parties deteriorated.

‘The Australian people are looking for a dynamism, they’re worried,’ Joyce said.

‘They’re dealing with the cost-of-living crisis, but it’s not just that, it’s what’s caused it. Bad policy.’

Hanson (pictured) said One Nation were not to be underestimated at the next federal election

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Despite questions about whether One Nation has the organisational depth to convert its strong polling into parliamentary seats, Hanson said the party was actively recruiting professional candidates and advisers.

‘Don’t underestimate One Nation because now we’ve got a lot of people from different backgrounds who are jumping on board with us, who want to actually see us succeed and are part of this journey with us,’ she said.

‘We’re building that strong team around us.’

‘Why we’re here is because we want to implement change for this country.’

The latest Newspoll released last Sunday showed One Nation leading on 30 per cent, while Labor slipped two points to 27 per cent. 

The Coalition was on 19 per cent and the Greens recorded 13 per cent.