Luann de Lesseps jokingly reacted to “The Real Housewives of New York City” being taken off the air after 15 seasons with one of her famous catchphrases.

The former “Housewife” left her funny remark Friday underneath a post Page Six’s Virtual Reali-Tea’s Instagram shared, which featured “RHONY is cancelled” memes alongside ex-cast member’s faces.

“How could you do this to me. Question Mark.” De Lesseps wrote in the comments section.

Several fans praised her witty comment, with one responding, “you are forever iconic!”

“I love that you have the best sense of humor!” another added, as a third wrote “the queen on rhony 👸🏻.”

The reality star, 59, unintentionally made the catchphrase go viral during Season 8 of “RHONY” in 2016 when she used text-to-speak to message her then-fiancé, Tom D’Agostino.

At the time, De Lesseps was confronting the businessman over photos of him kissing another woman.

The Bravo star ultimately decided to stay with D’agostino and they wed on New Year’s Eve later that year.

However, the couple then filed for divorce after seven months of marriage, with De Lesseps previously telling Page Six that they just “weren’t getting along.”

 “I do not think Tom cheated on me, definitely not. God knows he’s got himself in some trouble in the past, but I don’t believe that continued [while we were married],” she added.

The Bravolebrity starred on “RHONY” from Season 1 to Season 13, which aired in 2008 to 2021.

Page Six exclusively reported Friday that the flagship show was going off air with no plans to return in the near future.

“We’re trying to figure that show out. We want to figure it out. We think there’s still life in it,” a source told us at the time.

An insider further explained that if “RHONY” makes a comeback, viewers will see a whole new cast.

The drama series is the second-longest “Real Housewives” series, with “The Real Housewives of Orange County” show leading the way. However, it was revamped with a new cast in 2022.

Bravo appeared to be holding out hope for the future of the show, though, telling Page Six Friday, “Nothing is official. The show hasn’t been canceled.”

Bethenny Frankel, who was De Lesseps’ co-star for many seasons, shared her bittersweet reaction to the news via TikTok Friday.

“New York City was my playground and ‘The Real Housewives of New York City’ has been canceled. It’s poetic. It is bittersweet,” the Skinnygirl founder — who recently moved to Florida — admitted.

Frankel, 54, concluded, “People loved it because no matter what, it was real. It was the realest that genre can be. Bye, New York. You will be missed.”