DEIR EL-BALAH – Israeli strikes across Gaza killed at least 48 people, including women and children, hospital officials said Wednesday, as Israel prepares to ramp up its campaign against Hamas in a devastating war now entering its 20th month.

The strikes included one attack on Tuesday night on a school sheltering hundreds of displaced Palestinians, which killed 27 people, officials from the Al-Aqsa Hospital said, including nine women and three children. It was the fifth time since the war began that the school has been struck. Strikes on targets in several other areas killed at least 21.

A large column of smoke rose and fires pierced the dark skies above the school shelter in Bureij, a built-up urban refugee camp in central Gaza. Paramedics and rescuers rushed to pull people out from the blaze.

The Israeli military had no immediate comment on the strikes. Israel blames Hamas for the death toll because it operates from civilian infrastructure, including schools.

The new bloodshed comes days after Israel approved a plan to intensify its operations in the Palestinian enclave, which would include seizing Gaza, holding on to captured territories, forcibly displacing Palestinians to southern Gaza and taking control of aid distribution along with private security companies.

Israel is also calling up tens of thousands of reserve soldiers to carry out the plan. Israel says the plan will be gradual and will not be implemented until after U.S. President Donald Trump wraps up his visit to the region later this month.

Any escalation of fighting would likely drive up the death toll. And with Israel already controlling some 50% of Gaza, increasing its hold on the territory, for an indefinite amount of time, could open up the potential for a military occupation, which would raise questions about how Israel plans to have the territory governed, especially at a time when it is considering how to implement Trump’s vision to take over Gaza.

Trump jars Israelis with remark on hostage figures

The war began when Hamas-led militants attacked southern Israel, killing 1,200 people and taking about 250 hostages. Israel’s offensive has killed more than 52,000 people in Gaza, many of them women and children, according to Palestinian health officials. The officials do not distinguish between combatants and civilians in their count.

Trump on Tuesday stunned many in Israel when he declared that only 21 of the 59 hostages remaining in Gaza are still alive. Israel insists that figure stands at 24, although an Israeli official said there was “serious concern” for the lives of three captives. The official said there has been no sign of life from those three, whom the official did not identify. He said that until there is evidence proving otherwise, the three are considered to be alive. The official, who spoke on condition of anonymity to discuss sensitive details related to the war, said the families of the captives were updated on those developments.

The Hostages and Missing Families Forum, a group representing the families of the captives, demanded from Israel’s government that if there is “new information being kept from us, give it to us immediately.” It also called for Israeli Prime Minister Benjamin Netanyahu to halt the war in Gaza until all hostages are returned. “This is the most urgent and important national mission,” it said on a post on X.

Since Israel ended a ceasefire with the Hamas militant group in mid-March, it has unleashed fierce strikes on Gaza that have killed hundreds and has captured swaths of territory. Before the truce ended, Israel halted all humanitarian aid into the territory, including food, fuel and water, setting off what is believed to the be the worst humanitarian crisis in 19 months of war.

Key interlocutors Qatar and Egypt said Wednesday that mediation efforts were “ongoing and consistent.” But Israel and Hamas remain far apart on how they see the war ending. Israel says it won’t end the war until Hamas’ governing and military capabilities are dismantled, something it has failed to do in 19 months of war. Hamas says it is prepared to release all of the hostages for an end to the war and a long term truce with Israel.

The US-Houthi deal does not appear to cover Israel

Against the backdrop of the plans to intensify the campaign in Gaza, fighting has also escalated between Israel and Iranian-backed Houthi rebels in Yemen.

The Houthis fired a ballistic missile earlier this week that landed on the grounds of Israel’s main international airport. Israel responded with a series of airstrikes over two days, whose targets included the airport in Yemen’s capital, Sanaa.

The Houthis have been striking Israel and targets in a main Red Sea shipping route since the war began in solidarity with the Palestinians. On Tuesday, Trump said the U.S. would halt a nearly two-monthlong campaign against the Houthis in Yemen, after the rebel group agreed not to target U.S. ships.

Israel does not appear to be covered by the U.S.-Houthi agreement.

The Israeli official said the deal came as a surprise to Israel and that it was concerned by it because of what it meant for the continuation of hostilities between it and the Houthis.

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Goldenberg reported from Tel Aviv, Israel.

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