Stefanos Tsitsipas vs. Alexandre Muller odds, prediction
Share and Follow

Stefanos Tsitsipas’ career is at a crossroads ahead of his first match at this year’s US Open.

The highly skilled Greek player has faced a tumultuous journey in 2025, leading some critics to think that Tsitsipas has already peaked in his tennis career.

This might sound severe for someone who was still among the top 10 players just four months back, yet this shows how frustrating Tsitsipas’ performances have been this summer.

His inconsistency, combined with various off-court dramas, has resulted in Tsitsipas being a less favored contender against Alexandre Muller in the first round of the US Open on Tuesday.

US Open: Tsitsipas vs. Muller odds, prediction

Player Odds
Stefanos Tsitsipas -200
Alexandre Muller +162
Odds via bet365

It’s hard to believe the form that Tsitsipas is in right now. The former World No. 3 has lost six of his last eight matches, with five of the defeats coming against players ranked outside the top 60.

It’s been four months since Tsitsipas won two matches in a row, and he hasn’t strung together three straight wins since winning his first two matches at Indian Wells on the heels of his title in Dubai in February.


Alexandre Muller playing tennis at the Cincinnati Open.
World No. 38 Alexandre Muller has struggled in recent months. IMAGN IMAGES via Reuters Connect

Despite this hard-to-believe stretch, Tsitsipas remains the No. 28 player in the world, which means he earned a seed for the 2025 US Open.

And while it may seem like the draw was unkind to him, planting him against No. 38 Alexandre Muller, this could be just what the doctor ordered for Tsitsipas, who always has a ton of support from the crowd in New York City thanks to the area’s Greek population.

Muller, like Tsitsipas, has come off the boil lately with just four wins in his last 13 matches, and a 27-30 record over the last 52 weeks.

The Frenchman will relish the opportunity to get back into form against another struggling player, but there have been no real signs that the 28-year-old is coming out of his rut.

Additionally, this tournament hasn’t been too kind to Muller in the past, as the Frenchman has played just three main-draw matches, with one win in his career.

Tsitsipas will have the crowd behind him on Tuesday, and he’ll get an opponent who is also standing on shaky ground.

This is a chance to buy low on the talented Tsitsipas and hope he finally gets his act together.

If he does have his game clicking, he could make very quick work of the struggling Muller.

The Play: Tsitsipas -2.5 sets (+275, bet365)


Why Trust New York Post Betting

Michael Leboff is a long-suffering Islanders fan, but a long-profiting sports bettor with 10 years of experience in the gambling industry. He loves using game theory to help punters win bracket pools, find long shots, and learn how to beat the market in mainstream and niche sports.

Share and Follow
You May Also Like
Trump announces escalating tariffs on Denmark and other European nations to force Greenland purchase deal

Trump’s Tariff Tactics: Pressuring Denmark and Europe in Greenland Acquisition Quest

President Donald Trump has declared that the United States will implement a…
FBI captures Top Ten Most Wanted fugitive in Mexico sought over 2016 murder of NC co-worker

FBI Nabs Elusive Fugitive in Mexico: Breakthrough in 2016 NC Murder Case

The FBI revealed on Saturday that Alejandro Rosales Castillo, who had been…
bet365 bonus code NYPBET: Bet $5, get $200 in bonus bets for 49ers vs. Seahawks

Unlock $200 in Bonus Bets with a $5 Wager on 49ers vs. Seahawks Using NYPBET Code at Bet365

Gambling content 21+. The New York Post may receive an affiliate commission…
US troops pull out of major Iraq airbase amid ongoing regional consolidation effort, progress against ISIS

US Troops Withdraw from Key Iraq Airbase as Regional Strategy Against ISIS Advances

The United States has completed the withdrawal of its troops from the…
The astonishing sign my wife sent me from beyond the grave

Unbelievable: Husband Receives Astonishing Message from Deceased Wife, Sparking Conversations on Afterlife

In my Montana backyard stands a tranquil grove of century-old pines, their…
China's secret plan to infiltrate America with sleeper citizens

Unveiling China’s Covert Strategy: The Rise of Sleeper Citizens in America

In the serene suburbs of California, a new and unsettling form of…
Rams-Bears game Sunday: Bears fan rally held downtown Chicago Saturday as NFL divisional round weekend kicks off

Chicago Bears Fans Ignite Downtown Rally Ahead of Epic Rams Showdown

CHICAGO (WLS) — Chicago is buzzing with excitement as Bears fans gear…
'Bug' Broadway show abruptly cancels preview performance due to illness

Carrie Coon Reveals Health Scare: The Untold Story Behind Her ‘Bug’ Broadway Debut Delay

Despite an initial scare, the premiere of the Broadway show went ahead…