Stefanos Tsitsipas vs. Alexandre Muller odds, prediction
Share and Follow

Stefanos Tsitsipas’ career is at a crossroads ahead of his first match at this year’s US Open.

The highly skilled Greek player has faced a tumultuous journey in 2025, leading some critics to think that Tsitsipas has already peaked in his tennis career.

This might sound severe for someone who was still among the top 10 players just four months back, yet this shows how frustrating Tsitsipas’ performances have been this summer.

His inconsistency, combined with various off-court dramas, has resulted in Tsitsipas being a less favored contender against Alexandre Muller in the first round of the US Open on Tuesday.

US Open: Tsitsipas vs. Muller odds, prediction

Player Odds
Stefanos Tsitsipas -200
Alexandre Muller +162
Odds via bet365

It’s hard to believe the form that Tsitsipas is in right now. The former World No. 3 has lost six of his last eight matches, with five of the defeats coming against players ranked outside the top 60.

It’s been four months since Tsitsipas won two matches in a row, and he hasn’t strung together three straight wins since winning his first two matches at Indian Wells on the heels of his title in Dubai in February.


Alexandre Muller playing tennis at the Cincinnati Open.
World No. 38 Alexandre Muller has struggled in recent months. IMAGN IMAGES via Reuters Connect

Despite this hard-to-believe stretch, Tsitsipas remains the No. 28 player in the world, which means he earned a seed for the 2025 US Open.

And while it may seem like the draw was unkind to him, planting him against No. 38 Alexandre Muller, this could be just what the doctor ordered for Tsitsipas, who always has a ton of support from the crowd in New York City thanks to the area’s Greek population.

Muller, like Tsitsipas, has come off the boil lately with just four wins in his last 13 matches, and a 27-30 record over the last 52 weeks.

The Frenchman will relish the opportunity to get back into form against another struggling player, but there have been no real signs that the 28-year-old is coming out of his rut.

Additionally, this tournament hasn’t been too kind to Muller in the past, as the Frenchman has played just three main-draw matches, with one win in his career.

Tsitsipas will have the crowd behind him on Tuesday, and he’ll get an opponent who is also standing on shaky ground.

This is a chance to buy low on the talented Tsitsipas and hope he finally gets his act together.

If he does have his game clicking, he could make very quick work of the struggling Muller.

The Play: Tsitsipas -2.5 sets (+275, bet365)


Why Trust New York Post Betting

Michael Leboff is a long-suffering Islanders fan, but a long-profiting sports bettor with 10 years of experience in the gambling industry. He loves using game theory to help punters win bracket pools, find long shots, and learn how to beat the market in mainstream and niche sports.

Share and Follow
You May Also Like
5 more arrests made in the investigation into Louvre jewel heist

Breaking News: Five Suspects Apprehended in Thrilling Louvre Jewel Heist Investigation

In a significant development concerning the heist of crown jewels from the…
Trump starts new nuclear arms race as he orders testing 'immediately'

Trump Initiates New Era in Nuclear Arms as He Calls for Swift Testing

In a bold move that could reshape global military dynamics, former U.S.…
Luigi Mangione gains prominence at federal jail where guards like him and inmates dub him 'ambassador': report

Luigi Mangione: The Inmate ‘Ambassador’ Gaining Popularity Among Guards and Prisoners in Federal Jail

Luigi Mangione, the man accused of attempting to assassinate the CEO of…
'Son of Concorde' supersonic jet takes to the skies for the first time

Next-Gen Supersonic Jet Makes Its Maiden Flight, Heralding a New Era in Air Travel

In a landmark moment nearly ten years in the making, NASA’s supersonic…
Chicago immigration operations: Appeals court blocks order requiring CBP Chief Greg Bovino to meet with judge every day on

Appeals Court Halts Daily Meeting Mandate for CBP Chief Greg Bovino in Chicago Immigration Operations Case

The U.S. Department of Justice is challenging a federal judge’s directive that…
Trump, China's Xi set face-to-face meeting in South Korea

Historic Trump-Xi Summit Set for South Korea: What This Means for US-China Relations

A highly anticipated face-to-face meeting between Chinese President Xi Jinping and U.S.…
Meghan and Harry 'are booed' by crowd at Dodgers Stadium

Meghan and Harry Receive Mixed Reactions from Crowd at Dodgers Stadium

Harry and Meghan were seen smiling amid what seemed to be a…
President Donald Trump shakes hands with South Korean President Lee Jae Myung as he receives a gift of a gold crown and an award of the Grand Order of Mugunghwa, not seen, during a high honor ceremony at the Gyeongju National Museum in Gyeongju, South Korea, Wednesday, Oct. 29, 2025. (AP Photo/Mark Schiefelbein)

Trump Announces US-South Korea Collaboration on Nuclear Submarine Technology

GYEONGJU, South Korea (AP) — President Donald Trump announced via social media…