Stefanos Tsitsipas vs. Alexandre Muller odds, prediction
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Stefanos Tsitsipas’ career is at a crossroads ahead of his first match at this year’s US Open.

The highly skilled Greek player has faced a tumultuous journey in 2025, leading some critics to think that Tsitsipas has already peaked in his tennis career.

This might sound severe for someone who was still among the top 10 players just four months back, yet this shows how frustrating Tsitsipas’ performances have been this summer.

His inconsistency, combined with various off-court dramas, has resulted in Tsitsipas being a less favored contender against Alexandre Muller in the first round of the US Open on Tuesday.

US Open: Tsitsipas vs. Muller odds, prediction

Player Odds
Stefanos Tsitsipas -200
Alexandre Muller +162
Odds via bet365

It’s hard to believe the form that Tsitsipas is in right now. The former World No. 3 has lost six of his last eight matches, with five of the defeats coming against players ranked outside the top 60.

It’s been four months since Tsitsipas won two matches in a row, and he hasn’t strung together three straight wins since winning his first two matches at Indian Wells on the heels of his title in Dubai in February.


Alexandre Muller playing tennis at the Cincinnati Open.
World No. 38 Alexandre Muller has struggled in recent months. IMAGN IMAGES via Reuters Connect

Despite this hard-to-believe stretch, Tsitsipas remains the No. 28 player in the world, which means he earned a seed for the 2025 US Open.

And while it may seem like the draw was unkind to him, planting him against No. 38 Alexandre Muller, this could be just what the doctor ordered for Tsitsipas, who always has a ton of support from the crowd in New York City thanks to the area’s Greek population.

Muller, like Tsitsipas, has come off the boil lately with just four wins in his last 13 matches, and a 27-30 record over the last 52 weeks.

The Frenchman will relish the opportunity to get back into form against another struggling player, but there have been no real signs that the 28-year-old is coming out of his rut.

Additionally, this tournament hasn’t been too kind to Muller in the past, as the Frenchman has played just three main-draw matches, with one win in his career.

Tsitsipas will have the crowd behind him on Tuesday, and he’ll get an opponent who is also standing on shaky ground.

This is a chance to buy low on the talented Tsitsipas and hope he finally gets his act together.

If he does have his game clicking, he could make very quick work of the struggling Muller.

The Play: Tsitsipas -2.5 sets (+275, bet365)


Why Trust New York Post Betting

Michael Leboff is a long-suffering Islanders fan, but a long-profiting sports bettor with 10 years of experience in the gambling industry. He loves using game theory to help punters win bracket pools, find long shots, and learn how to beat the market in mainstream and niche sports.

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